Kawaguchi S
First Department of Pathology, Nippon Medical School, Tokyo, Japan.
Acta Pathol Jpn. 1988 Jan;38(1):1-10. doi: 10.1111/j.1440-1827.1988.tb01067.x.
Serial renal biopsies were performed to observe in detail the age-related glomerular IgA deposition in ddY mice. Moreover, lymphocytes from spleens and Peyer's patches (PP) were immunologically examined in the mice at 10 months of age. The incidence of IgA deposition in the glomeruli was 0% at 3 months, 33% at 7 months, 60% at 10 months and 100% at 13 months, but IgA deposits were less intense than IgG and IgM deposits. Serum levels of IgA and polyclonal IgA responses of PP cells were significantly higher in the mice with glomerular IgA deposits. However, neither the Lyt-1+/Lyt-2+ cell ratio nor the polyclonal IgA responses of spleen cells were related to IgA deposition. Therefore, gut-associated lymphoreticular tissue (GALT) probably plays an important role in the pathogenesis of the high IgA response and glomerular IgA deposition observed in this strain. These results suggest that ddY mice would be valuable as a model of spontaneous glomerular IgA deposition, as well as being useful for studying the possible relationship between the mucosal immune system and glomerular IgA deposition.
进行系列肾脏活检以详细观察ddY小鼠中与年龄相关的肾小球IgA沉积。此外，对10月龄小鼠脾脏和派伊尔结（PP）中的淋巴细胞进行了免疫学检测。肾小球中IgA沉积的发生率在3个月时为0%，7个月时为33%，10个月时为60%，13个月时为100%，但IgA沉积物的强度低于IgG和IgM沉积物。肾小球有IgA沉积的小鼠血清IgA水平和PP细胞的多克隆IgA反应显著更高。然而，脾脏细胞的Lyt-1+/Lyt-2+细胞比例和多克隆IgA反应均与IgA沉积无关。因此，肠道相关淋巴组织（GALT）可能在该品系中观察到的高IgA反应和肾小球IgA沉积的发病机制中起重要作用。这些结果表明，ddY小鼠作为自发性肾小球IgA沉积的模型将具有价值，并且对于研究黏膜免疫系统与肾小球IgA沉积之间的可能关系也很有用。
