荷兰危重症患者血流感染大肠杆菌的 O 血清型分布。
O-serotype distribution of Escherichia coli bloodstream infection isolates in critically ill patients in The Netherlands.
机构信息
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Intensive Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Intensive Care, University Medical Center Utrecht, Utrecht, the Netherlands.
出版信息
Vaccine. 2021 Mar 19;39(12):1670-1674. doi: 10.1016/j.vaccine.2021.02.031. Epub 2021 Feb 25.
OBJECTIVES
Invasive infections by extra-intestinal pathogenic Escherichia coli (ExPEC) strains are increasing. We determined O-serogroups of E. coli isolates from ICU patients having bloodstream infections (BSI) and the potential coverage of a 10-valent O-polysaccharide conjugate vaccine currently in development for the prevention of invasive ExPEC disease.
METHODS
We studied E. coli BSI among patients admitted to a tertiary ICU in the Netherlands between April 2011 and November 2016. O-serogroups were determined in vitro by agglutination and whole genome sequencing.
RESULTS
Among 714 ICU patients having BSI, 70 (10%) had an E. coli BSI. Among 68 (97%) isolates serogrouped, the most common serogroups were O25 (n = 11; 16%), O8 (n = 5; 7%), O2 (n = 4; 6%), O6 (n = 4; 6%), and O15 (n = 4; 6%). The theoretical coverage of a 10-valent ExPEC vaccine was 54% (n = 37).
CONCLUSIONS
A multi-valent ExPEC O-polysaccharide conjugate vaccine in development could potentially aid in the prevention of E. coli BSI in Dutch ICU patients.
目的
肠外致病性大肠杆菌（ExPEC）菌株的侵袭性感染正在增加。我们确定了来自 ICU 患者血流感染（BSI）的大肠杆菌分离株的 O 血清群，并评估了目前正在开发的用于预防侵袭性 ExPEC 疾病的 10 价 O 多糖结合疫苗的潜在覆盖范围。
方法
我们研究了 2011 年 4 月至 2016 年 11 月期间在荷兰一家三级 ICU 住院的患者中大肠杆菌 BSI 的情况。通过凝集和全基因组测序在体外确定 O 血清群。
结果
在 714 例 ICU 患者发生 BSI 中，有 70 例（10%）为大肠杆菌 BSI。在 68 例（97%）可分血清群的分离株中，最常见的血清群为 O25（n=11；16%）、O8（n=5；7%）、O2（n=4；6%）、O6（n=4；6%）和 O15（n=4；6%）。理论上 10 价 ExPEC 疫苗的覆盖率为 54%（n=37）。
结论
正在开发的多价 ExPEC O 多糖结合疫苗可能有助于预防荷兰 ICU 患者的大肠杆菌 BSI。
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