Department of Medicine, LASUTH/LASUCOM, Ikeja, Nigeria.
Department of Obstetrics and Gynaecology, LASUTH/LASUCOM, Ikeja, Nigeria.
Niger Postgrad Med J. 2021 Jan-Mar;28(1):68-70. doi: 10.4103/npmj.npmj_344_20.
The choice and regimen of anticoagulation therapy in pregnant women with mechanical valve prostheses have always been a daunting task. It is a delicate balance that takes into consideration the risk of thromboembolic complications in the mother and the risk of potential Warfarin embryopathy to the foetus. Medical practice in a low socioeconomic setting also has the peculiar challenge of financial constraints on the part of the patients and difficulties in monitoring the efficacy of anticoagulation therapy. We report our experience in managing two pregnant women with mechanical valve prostheses and review the existing literature on this complex but interesting subject.
在患有机械瓣膜假体的孕妇中选择和制定抗凝治疗方案一直是一项艰巨的任务。这是一个需要谨慎权衡的问题，需要考虑到母亲发生血栓栓塞并发症的风险，以及华法林对胎儿潜在的胚胎病风险。在低社会经济环境下的医疗实践还具有患者经济限制的特殊挑战，以及监测抗凝治疗效果的困难。我们报告了管理两名患有机械瓣膜假体的孕妇的经验，并回顾了这一复杂但有趣的主题的现有文献。
