Faithfull N S, Fennema M, Erdmann W
Department of Anaesthesia, University of Manchester, UK.
Adv Exp Med Biol. 1988;222:473-80. doi: 10.1007/978-1-4615-9510-6_56.
Previous work by the authors has shown that, following ligation of the left anterior descending coronary artery (LAD), myocardial oxygen tension (PmO2) in expected areas of maximal ischaemia is maintained at the expense of ischaemic border zones of the infarct area. Post-ischaemic haemodilution with the fluorocarbon containing plasma substitute Fluosol-DA 20% (FDA) could significantly improve PmO2 and pre-ischaemic haemodilution can delay myocardial ischaemia. We now present an analysis of the pattern of PmO2 changes to be seen when myocardial ischaemia is induced following prior haemodilution with FDA. Two groups of juvenile Yorkshire pigs were anaesthetised with intraperitoneal thiopentone, intubated and ventilated with halothane, nitrous oxide and oxygen. After placement of cardiovascular monitoring lines, a thoracotomy was performed. The pericardium was opened and 4 steel-protected gold microelectrodes were placed in the terminal supply area of the LAD in such a way that 2 electrodes were in the area of myocardial ischaema to be produced. One group of pigs were bled (20 ml/kg) and the loss was replaced with equal volumes of FDA. The animals were ventilated with halothane and oxygen and the terminal LAD was ligated. Electrode outputs were recorded on a flat bed recorder and analysed. LAD occlusion in the control animals resulted in similar changes in PmO2 to those described above.(ABSTRACT TRUNCATED AT 250 WORDS)
作者之前的研究表明，在结扎左冠状动脉前降支（LAD）后，最大缺血预期区域的心肌氧分压（PmO2）得以维持，但以梗死区域的缺血边缘区为代价。使用含氟碳化合物的血浆代用品氟碳乳剂-DA 20%（FDA）进行缺血后血液稀释可显著改善PmO2，而缺血前血液稀释可延迟心肌缺血。我们现在呈现对在用FDA进行预先血液稀释后诱导心肌缺血时所观察到的PmO2变化模式的分析。两组幼年约克夏猪用腹腔注射硫喷妥钠麻醉，插管并用氟烷、氧化亚氮和氧气通气。放置心血管监测线后，进行开胸手术。打开心包，将4根带钢保护的金微电极置于LAD的终末供血区域，使2根电极位于即将产生的心肌缺血区域。一组猪放血（20毫升/千克），失血用等量的FDA替代。动物用氟烷和氧气通气，然后结扎LAD终末段。电极输出在平板记录仪上记录并分析。对照动物的LAD闭塞导致PmO2出现与上述相似的变化。（摘要截短于250字）
