Faithfull N S, Fennema M, Erdmann W
Department of Anaesthesia, Hope Hospital, Salford.
Br J Anaesth. 1988 Jun;60(7):773-8. doi: 10.1093/bja/60.7.773.
The possible prophylactic effects of Fluosol-DA 20% (FDA) haemodilution against myocardial hypoxia were studied in two groups of anaesthetized immature pigs. Precalibrated 200-micron diameter oxygen microelectrodes were inserted to the myocardium of the left ventricle. One group of animals was haemodiluted with FDA and both groups received 100% oxygen (plus halothane). The lower one-third of the left anterior descending coronary artery was occluded; this caused no significant cardiovascular changes. Analysis from the microelectrodes in the most hypoxic areas of the myocardium revealed significant decreases in myocardial oxygen tension (PmO2) in the control group 15 min after occlusion in the FDA-diluted group. Analysis of other electrodes suggested greater hyperaemic compensatory response in ischaemic border areas in the FDA-treated group.
在两组麻醉的未成年猪中研究了20%氟碳代血液（FDA）血液稀释对心肌缺氧的可能预防作用。将预先校准的直径为200微米的氧微电极插入左心室心肌。一组动物用FDA进行血液稀释，两组均接受100%氧气（加氟烷）。左前降支冠状动脉下三分之一被阻断；这未引起明显的心血管变化。对心肌最缺氧区域的微电极分析显示，在FDA稀释组中，阻断后15分钟对照组的心肌氧张力（PmO2）显著降低。对其他电极的分析表明，FDA治疗组缺血边缘区域的充血性代偿反应更强。
