Raj Tigapuram Kamal Nitheesh, Gupta Kirti, Sood Ashwani, Singla Navneet, Rana Nivedita, Vatsa Rakhee, Ahuja Chirag Kamal, Mittal Bhagwant Rai
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Nucl Med. 2020 Oct-Dec;35(4):367-369. doi: 10.4103/ijnm.IJNM_135_20. Epub 2020 Oct 21.
The recent WHO classification of gliomas has incorporated molecular markers such as isocitrate dehydrogenase () mutation and 1p/19q co-deletion into the ambit of morphological diagnosis, and 18F-fluoro-ethyl-tyrosine (F-FET) positron emission tomography (PET) has shown its utility in noninvasive glioma grading and prognosis. Both dynamic and static FET PET parameters may assist in predicting the mutational status, but time to peak derived from dynamic data may be a better predictor for status. We present a case of left frontal lobe lesion suggestive of high-grade glioma on magnetic resonance imaging and static F-FET PET images, however, dynamic FET image was suggestive of low-grade -mutated glioma which was later confirmed on histology and immunohistochemistry.
世界卫生组织（WHO）近期对胶质瘤的分类已将异柠檬酸脱氢酶（IDH）突变和1p/19q共缺失等分子标志物纳入形态学诊断范畴，且18F-氟代乙基酪氨酸（F-FET）正电子发射断层扫描（PET）已显示出其在胶质瘤无创分级和预后评估中的作用。动态和静态FET PET参数均可能有助于预测IDH突变状态，但从动态数据得出的达峰时间可能是IDH状态更好的预测指标。我们报告1例磁共振成像和静态F-FET PET图像提示左额叶病变为高级别胶质瘤的病例，然而，动态FET图像提示为低级别IDH突变型胶质瘤，随后经组织学和免疫组化得以证实。
