Kliczkowska-Klarowicz Katarzyna, Jagielski Dariusz, Czopowicz Michał, Sapierzyński Rafał A
Department of Pathology and Veterinary Diagnostics, Division of Pathology, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-776 Warsaw, Poland.
Białobrzeska Veterinary Surgery in Warsaw, Poland.
Vet World. 2021 Jan;14(1):49-55. doi: 10.14202/vetworld.2021.49-55. Epub 2021 Jan 7.
Centroblastic lymphoma (CBL) is the most common morphological type of lymphoma found in dogs; it is usually identified through cytology in veterinary clinical practice. This study aimed to identify the demographic and clinical characteristics of dogs with CBL that was diagnosed with cytology and immunocytochemistry.
Dogs with a suspicion of lymphoma were diagnosed by cytology supported by immunocytochemistry with the use of the updated Kiel classification adapted for dogs. During the analyzed time period, 336 lymphomas were diagnosed in dogs, including 171 cases of CBL. Epidemiological and clinical data from the dogs with CBL were provisionally collected.
The epidemiology analysis revealed an increased risk of CBL in Rottweilers, golden retrievers, and Bernese mountain dogs. At admission, most of the dogs displayed generalized lymphadenopathy with spleen and liver enlargement. The most common hematological abnormality was leukocytosis due to neutrophilia. The most common biochemical abnormality was elevated alanine aminotransferase and alkaline phosphatase activities and selective hypoproteinemia due to hypoalbuminemia.
Rottweilers, Bernese mountain dogs, and golden retrievers appear to be overrepresented among dogs with CBL. CBL is usually diagnosed at an advanced clinical stage according to the World Health Organization; however, it is usually accompanied by only minor hematological and biochemical abnormalities.
中心母细胞性淋巴瘤（CBL）是犬类中最常见的淋巴瘤形态学类型；在兽医临床实践中通常通过细胞学检查来识别。本研究旨在确定经细胞学和免疫细胞化学诊断为CBL的犬的人口统计学和临床特征。
对疑似淋巴瘤的犬进行细胞学诊断，并通过免疫细胞化学进行支持，采用适用于犬的更新后的基尔分类法。在分析时间段内，犬类共诊断出336例淋巴瘤，其中包括171例CBL。临时收集了患有CBL的犬的流行病学和临床数据。
流行病学分析显示，罗威纳犬、金毛寻回犬和伯恩山犬患CBL的风险增加。入院时，大多数犬表现为全身性淋巴结病伴脾脏和肝脏肿大。最常见的血液学异常是由于中性粒细胞增多导致的白细胞增多。最常见的生化异常是丙氨酸转氨酶和碱性磷酸酶活性升高以及由于低白蛋白血症导致的选择性低蛋白血症。
罗威纳犬、伯恩山犬和金毛寻回犬在患有CBL的犬中所占比例似乎过高。根据世界卫生组织的标准，CBL通常在临床晚期被诊断出来；然而，它通常仅伴有轻微的血液学和生化异常。
