口吃成年人中脑铁沉积扩大区域
Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter.
作者信息
Liman Jan, Wolff von Gudenberg Alexander, Baehr Mathias, Paulus Walter, Neef Nicole E, Sommer Martin
机构信息
Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Institut der Kasseler Stottertherapie (KST), Bad Emstal, Germany.
出版信息
Front Hum Neurosci. 2021 Feb 11;15:639269. doi: 10.3389/fnhum.2021.639269. eCollection 2021.
PURPOSE
Childhood onset speech fluency disorder (stuttering) is possibly related to dopaminergic dysfunction. Mesencephalic hyperechogenicity (ME) detected by transcranial ultrasound (TCS) might be seen as an indirect marker of dopaminergic dysfunction. We here determined whether adults who stutter since childhood (AWS) show ME.
METHODS
We performed TCS in ten AWS and ten matched adults who never stuttered. We also assessed motor performance in finger tapping and in the 25 Foot Walking test.
RESULTS
Compared to controls, AWS showed enlarged ME on either side. Finger tapping was slower in AWS. Walking cadence, i.e., the ratio of number of steps by time, tended to be higher in AWS than in control participants.
DISCUSSION
The results demonstrate a motor deficit in AWS linked to dopaminergic dysfunction and extending beyond speech. Since iron deposits evolve in childhood and shrink thereafter, ME might serve as an easily quantifiable biomarker helping to predict the risk of persistency in children who stutter.
目的
儿童期起病的言语流畅性障碍（口吃）可能与多巴胺能功能障碍有关。经颅超声（TCS）检测到的中脑高回声（ME）可能被视为多巴胺能功能障碍的间接标志物。我们在此确定自幼口吃的成年人（AWS）是否存在ME。
方法
我们对10名AWS和10名匹配的从不口吃的成年人进行了TCS检查。我们还评估了手指敲击和25英尺步行测试中的运动表现。
结果
与对照组相比，AWS两侧的ME均增大。AWS的手指敲击较慢。AWS的步行节奏，即步数与时间的比率，往往高于对照组参与者。
讨论
结果表明，AWS存在与多巴胺能功能障碍相关且超出言语范畴的运动缺陷。由于铁沉积在儿童期发展并随后缩小，ME可能作为一种易于量化的生物标志物，有助于预测口吃儿童持续存在口吃的风险。
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