给予H2受体拮抗剂对甲状腺中I-131 24小时摄取的影响。
The Influence of H2-Receptor Antagonist Administration to the 24-h Uptake of I-131 in the Thyroid Gland.
作者信息
Lim Andreas, Budiawan Hendra, Kartamihardja A Hussein S
机构信息
Department of Nuclear Medicine and Molecular Imaging, Dr. Hasan Sadikin General Hospital Bandung, Pasirkaliki 192, Sukajadi, Pasteur, Bandung, West Java 40161 Indonesia.
Universitas Padjadjaran Bandung, Bandung, Indonesia.
出版信息
Nucl Med Mol Imaging. 2021 Feb;55(1):27-30. doi: 10.1007/s13139-020-00676-1. Epub 2021 Jan 7.
PURPOSE
The aim of this study was to determine the influence of H2RAs to the 24-h I-131 uptake in the thyroid gland.
MATERIAL AND METHODS
A prospective study with quasi-experimental pre- and post-study design was done. Subjects with normal fT4 level who fulfilled the inclusion criteria were selected. All subjects received 0.2 mCi of I-131 orally, and the thyroid uptake calculations were performed at 24 h later. The same procedure was performed 4 weeks later. All of the subjects were asked to consume H2RAs 1 h before the administration of I-131 of the second procedure. Both 24-h thyroid uptakes were statistically analysed.
RESULTS
A total of 14 subjects were enrolled in this study. Most of them were women (78%) with an average age of 37.6 years old (range: 20-55). This study showed a median of 24-h thyroid uptake of I-131 before and after H2-receptor antagonist of 20.6% (range: 11.1-57.8%) and 16.7% (range: 8.1-39.4%) respectively.
CONCLUSION
H2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland.
目的
本研究的目的是确定H2受体拮抗剂对甲状腺24小时I-131摄取的影响。
材料与方法
采用前瞻性研究，设计了准实验性的研究前和研究后方案。选择符合纳入标准且fT4水平正常的受试者。所有受试者口服0.2毫居里的I-131，并在24小时后进行甲状腺摄取计算。4周后重复相同程序。所有受试者在第二次程序给予I-131前1小时服用H2受体拮抗剂。对两次24小时甲状腺摄取进行统计学分析。
结果
本研究共纳入14名受试者。其中大多数为女性（78%），平均年龄37.6岁（范围：20 - 55岁）。本研究显示，H2受体拮抗剂使用前和使用后I-131的24小时甲状腺摄取中位数分别为20.6%（范围：11.1 - 57.8%）和16.7%（范围：8.1 - 39.4%）。
结论
H2受体拮抗剂导致甲状腺24小时I-131摄取值显著降低。
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