Ekhtelat Maryam, Khalili Borujeni Farzaneh, Siahpoosh Amir, Ameri Abdolghani
Medicinal Plant Research Center, Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Vet Res Forum. 2020 Fall;11(4):333-338. doi: 10.30466/vrf.2018.93152.2248. Epub 2020 Dec 15.
Side effects of chemical preservatives and drug resistance have raised interest in use of herbal products. This study aimed to examine the chemical composition and antibacterial effects of , and essential oils individually and in combination with sodium benzoate against methicillin-resistant and The essential oils were analyzed by gas chromatography-mass spectrometry. Disc diffusion and microdilution assays were used for antimicrobial screening. The main components were cumin aldehyde, carvone, and pulegone in , and essential oils, respectively. Antibacterial data analysis showed significant differences between different antibacterial effects of essential oils individually and in combination with sodium benzoate. In terms of individual effects, antibacterial effect of and essential oils were the highest against methicillin-resistant and respectively. The antibacterial effects of sodium benzoate combined with essential oils showed significant differences with the individual effect of sodium benzoate in most cases. The results indicated that the combined effect of these essential oils with sodium benzoate could reduce the use of sodium benzoate as an antimicrobial agent, which could decrease its possible side effects. Thus, for more significant effects, these essential oils could be combined with other agents for the preservation of drug and food products.
化学防腐剂的副作用和耐药性引发了人们对使用草药产品的兴趣。本研究旨在单独检测[具体植物名称1]、[具体植物名称2]和[具体植物名称3]精油的化学成分及抗菌效果，以及它们与苯甲酸钠联合使用对耐甲氧西林金黄色葡萄球菌和[另一种细菌名称]的抗菌效果。通过气相色谱 - 质谱联用仪分析精油成分。采用纸片扩散法和微量稀释法进行抗菌筛选。[具体植物名称1]、[具体植物名称2]和[具体植物名称3]精油的主要成分分别为枯茗醛、香芹酮和胡薄荷酮。抗菌数据分析表明，精油单独使用以及与苯甲酸钠联合使用时，不同的抗菌效果之间存在显著差异。就单独作用而言，[具体植物名称1]和[具体植物名称2]精油分别对耐甲氧西林金黄色葡萄球菌和[另一种细菌名称]的抗菌效果最佳。在大多数情况下，苯甲酸钠与精油联合使用的抗菌效果与苯甲酸钠单独使用的效果存在显著差异。结果表明，这些精油与苯甲酸钠联合使用可减少苯甲酸钠作为抗菌剂的使用量，从而降低其可能产生的副作用。因此，为获得更显著效果，这些精油可与其他制剂联合用于药品和食品的保存。
