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表现为肾上腺肿块的Castleman淋巴结病浆细胞变异型

Plasma cell variant of Castleman lymphadenopathy presenting as an adrenal mass.

作者信息

Mindiola-Romero Andres E, Seigne John D, Ornstein Deborah L

机构信息

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

Department of Surgery, Urology Section, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

出版信息

Urol Case Rep. 2021 Jan 26;36:101583. doi: 10.1016/j.eucr.2021.101583. eCollection 2021 May.

DOI:10.1016/j.eucr.2021.101583
PMID:33643847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7889820/
Abstract

Adrenal masses are commonly found on radiographic studies performed for unrelated reasons. We report on a case of a non-functioning adrenal mass from which a needle biopsy showed a nonspecific infiltrate of polyclonal plasma cells and small lymphocytes. A definitive diagnosis of the plasma cell variant of Castleman lymphadenopathy was made only after surgical excision. While the hyaline vascular variant of Castleman lymphadenopathy has been identified in adrenal glands, this is the first report of the plasma cell variant in an adrenal mass. This case particularly underscores the importance of an excisional biopsy for proper diagnosis.

摘要

肾上腺肿块通常在因无关原因进行的影像学检查中被发现。我们报告一例无功能肾上腺肿块病例,针吸活检显示多克隆浆细胞和小淋巴细胞的非特异性浸润。仅在手术切除后才确诊为Castleman淋巴结病的浆细胞变异型。虽然Castleman淋巴结病的透明血管变异型已在肾上腺中被发现,但这是肾上腺肿块中浆细胞变异型的首例报告。该病例特别强调了切除活检对于正确诊断的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176c/7889820/7aad673cc610/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176c/7889820/7aad673cc610/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176c/7889820/7aad673cc610/gr1.jpg

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引用本文的文献

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Analysis of characteristics of four patients with adrenal unicentric Castleman disease.四例肾上腺孤立性血管滤泡性中心性 Castleman 病患者的特征分析。
Front Endocrinol (Lausanne). 2023 May 17;14:1181929. doi: 10.3389/fendo.2023.1181929. eCollection 2023.

本文引用的文献

1
Overview of Castleman disease.卡斯特曼病概述。
Blood. 2020 Apr 16;135(16):1353-1364. doi: 10.1182/blood.2019000931.
2
Evaluation of an Adrenal Incidentaloma.肾上腺意外瘤的评估。
Surg Clin North Am. 2019 Aug;99(4):721-729. doi: 10.1016/j.suc.2019.04.009. Epub 2019 May 9.
3
Castleman's disease in the left suprarenal region, mimicking an adrenal neoplasm.左肾上腺区血管滤泡性淋巴组织增生症,类似于肾上腺肿瘤。
Urology. 2011 Aug;78(2):319. doi: 10.1016/j.urology.2010.12.031. Epub 2011 Feb 12.
4
Localized mediastinal lymphnode hyperplasia resembling thymoma.类似胸腺瘤的局限性纵隔淋巴结增生
Cancer. 1956 Jul-Aug;9(4):822-30. doi: 10.1002/1097-0142(195607/08)9:4<822::aid-cncr2820090430>3.0.co;2-4.
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Castleman's disease masquerading as an adrenal tumor.伪装成肾上腺肿瘤的卡斯特曼病。
J Urol. 2002 Dec;168(6):2524. doi: 10.1016/S0022-5347(05)64182-1.