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Polysaccharides From Lentinus Edodes Inhibits Lymphangiogenesis the Toll-Like Receptor 4/JNK Pathway of Cancer-Associated Fibroblasts.

作者信息

Wang Yuanyuan, Zeng Yanqiong, Zhu Linyu, Wan Jiajia, Lei Ningjing, Yao Xiaohan, Duan Xixi, Zhang Yana, Cheng Yanru, Tao Ning, Qin Zhihai

机构信息

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

School of Basic Medical Sciences of Southwest Medical University, Luzhou, China.

出版信息

Front Oncol. 2021 Feb 12;10:547683. doi: 10.3389/fonc.2020.547683. eCollection 2020.

DOI:10.3389/fonc.2020.547683
PMID:33643892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7907162/
Abstract

Polysaccharides from () have been successfully used as adjuvant chemotherapy drug to treat lymphatic metastasis in some malignancies, such as colorectal cancer (CRC), lung cancer and gastric cancer. The CRC could metastasize lymphatic vessels. Lymphatic metastasis is commonly thought to be the cause of poor prognosis of CRC. The mechanism of polysaccharides from inhibiting lymphatic metastasis of CRC is still unclear. In this study, we explored how MPSSS, a novel polysaccharide component of , influences lymphangiogenesis and lymph node metastasis. The results show that MPSSS can reduce lymphangiogenesis and lymphatic metastasis of CRC in mouse model. And combined with study, a likely mechanism is that MPSSS reduce the secretion of VEGF-C by cancer associated fibroblasts (CAFs). This effect can be suppressed by a TLR4 inhibitor, which suggests that MPSSS plays a role in CAFs through the TLR4/JNK signaling pathway. In conclusion, MPSSS may reduce lymphangiogenesis by decreasing the VEGF-C secretion of CAFs, which may provide a new strategy for the comprehensive treatment of CRC.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/3f369c31f565/fonc-10-547683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d7312eed6ca6/fonc-10-547683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d38dc7d92cac/fonc-10-547683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/8b135e5f6033/fonc-10-547683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/f66b4ac40f59/fonc-10-547683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/1ef01f39f96e/fonc-10-547683-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/61438373d7f8/fonc-10-547683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/3f369c31f565/fonc-10-547683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d7312eed6ca6/fonc-10-547683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d38dc7d92cac/fonc-10-547683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/8b135e5f6033/fonc-10-547683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/f66b4ac40f59/fonc-10-547683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/1ef01f39f96e/fonc-10-547683-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/61438373d7f8/fonc-10-547683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/3f369c31f565/fonc-10-547683-g007.jpg

相似文献

[1]
Polysaccharides From Lentinus Edodes Inhibits Lymphangiogenesis the Toll-Like Receptor 4/JNK Pathway of Cancer-Associated Fibroblasts.

Front Oncol. 2021-2-12

[2]
MPSSS impairs the immunosuppressive function of cancer-associated fibroblasts via the TLR4-NF-κB pathway.

Biosci Rep. 2019-5-10

[3]
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts.

J Nat Med. 2023-9

[4]
Proteomics reveals the function reverse of MPSSS-treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway.

Cancer Med. 2021-4

[5]
Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-κB/JNK pathways in colorectal cancer.

Oncotarget. 2016-11-8

[6]
CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer.

Theranostics. 2020

[7]
Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion.

Gastric Cancer. 2017-12-14

[8]
Semaphorin 4D expression is associated with a poor clinical outcome in cervical cancer patients.

Microvasc Res. 2014-5

[9]
Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion.

Gastroenterology. 2015-3-6

[10]
A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway.

Biomaterials. 2017-5-18

引用本文的文献

[1]
Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment.

J Transl Med. 2025-6-23

[2]
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier.

J Agric Food Chem. 2025-3-19

[3]
Immunomodulation aspects of gut microbiome-related interventional strategies in colorectal cancer.

Med Oncol. 2024-8-20

[4]
The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment.

Molecules. 2024-6-7

[5]
Mycochemicals against Cancer Stem Cells.

Toxins (Basel). 2023-5-25

[6]
The Effect of Novel Selenopolysaccharide Isolated from Mycelium on Human T Lymphocytes Activation, Proliferation, and Cytokines Synthesis.

Biomolecules. 2022-12-19

[7]
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.

Int J Biol Sci. 2022

[8]
Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model.

BMC Complement Med Ther. 2022-9-2

[9]
Ligustilide Inhibits Tumor Angiogenesis by Downregulating VEGFA Secretion from Cancer-Associated Fibroblasts in Prostate Cancer via TLR4.

Cancers (Basel). 2022-5-13

[10]
Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NF-κB signaling pathway in lung adenocarcinoma.

World J Surg Oncol. 2022-2-8

本文引用的文献

[1]
Pazopanib Inhibits Tumor Growth, Lymph-node Metastasis and Lymphangiogenesis of an Orthotopic Mouse of Colorectal Cancer.

Cancer Genomics Proteomics. 2020

[2]
Effects of pericytes and colon cancer stem cells in the tumor microenvironment.

Cancer Cell Int. 2019-7-1

[3]
MPSSS impairs the immunosuppressive function of cancer-associated fibroblasts via the TLR4-NF-κB pathway.

Biosci Rep. 2019-5-10

[4]
Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China.

J Cancer Res Clin Oncol. 2018-7-24

[5]
Identifying tumor promoting genomic alterations in tumor-associated fibroblasts via retrovirus-insertional mutagenesis.

Oncotarget. 2017-10-16

[6]
Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.

Sci Transl Med. 2017-9-13

[7]
Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.

Nat Commun. 2017-8-28

[8]
Origins of lymphatic and distant metastases in human colorectal cancer.

Science. 2017-7-7

[9]
High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer.

BMC Cancer. 2017-5-17

[10]
Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.

Cell Rep. 2016-10-25

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