• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

香菇多糖通过Toll样受体4/JNK途径抑制癌症相关成纤维细胞的淋巴管生成。

Polysaccharides From Lentinus Edodes Inhibits Lymphangiogenesis the Toll-Like Receptor 4/JNK Pathway of Cancer-Associated Fibroblasts.

作者信息

Wang Yuanyuan, Zeng Yanqiong, Zhu Linyu, Wan Jiajia, Lei Ningjing, Yao Xiaohan, Duan Xixi, Zhang Yana, Cheng Yanru, Tao Ning, Qin Zhihai

机构信息

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

School of Basic Medical Sciences of Southwest Medical University, Luzhou, China.

出版信息

Front Oncol. 2021 Feb 12;10:547683. doi: 10.3389/fonc.2020.547683. eCollection 2020.

DOI:10.3389/fonc.2020.547683
PMID:33643892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7907162/
Abstract

Polysaccharides from () have been successfully used as adjuvant chemotherapy drug to treat lymphatic metastasis in some malignancies, such as colorectal cancer (CRC), lung cancer and gastric cancer. The CRC could metastasize lymphatic vessels. Lymphatic metastasis is commonly thought to be the cause of poor prognosis of CRC. The mechanism of polysaccharides from inhibiting lymphatic metastasis of CRC is still unclear. In this study, we explored how MPSSS, a novel polysaccharide component of , influences lymphangiogenesis and lymph node metastasis. The results show that MPSSS can reduce lymphangiogenesis and lymphatic metastasis of CRC in mouse model. And combined with study, a likely mechanism is that MPSSS reduce the secretion of VEGF-C by cancer associated fibroblasts (CAFs). This effect can be suppressed by a TLR4 inhibitor, which suggests that MPSSS plays a role in CAFs through the TLR4/JNK signaling pathway. In conclusion, MPSSS may reduce lymphangiogenesis by decreasing the VEGF-C secretion of CAFs, which may provide a new strategy for the comprehensive treatment of CRC.

摘要

[具体来源]中的多糖已成功用作辅助化疗药物，用于治疗某些恶性肿瘤（如结直肠癌（CRC）、肺癌和胃癌）的淋巴转移。结直肠癌可通过淋巴管转移。淋巴转移通常被认为是结直肠癌预后不良的原因。[具体来源]中的多糖抑制结直肠癌淋巴转移的机制仍不清楚。在本研究中，我们探讨了[具体来源]的一种新型多糖成分MPSSS如何影响淋巴管生成和淋巴结转移。结果表明，MPSSS可减少小鼠模型中结直肠癌的淋巴管生成和淋巴转移。结合[相关]研究，一种可能的机制是MPSSS减少癌相关成纤维细胞（CAFs）分泌VEGF-C。TLR4抑制剂可抑制这种作用，这表明MPSSS通过TLR4/JNK信号通路在CAFs中发挥作用。总之，MPSSS可能通过减少CAFs分泌VEGF-C来减少淋巴管生成，这可能为结直肠癌的综合治疗提供一种新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/3f369c31f565/fonc-10-547683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d7312eed6ca6/fonc-10-547683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d38dc7d92cac/fonc-10-547683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/8b135e5f6033/fonc-10-547683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/f66b4ac40f59/fonc-10-547683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/1ef01f39f96e/fonc-10-547683-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/61438373d7f8/fonc-10-547683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/3f369c31f565/fonc-10-547683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d7312eed6ca6/fonc-10-547683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/d38dc7d92cac/fonc-10-547683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/8b135e5f6033/fonc-10-547683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/f66b4ac40f59/fonc-10-547683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/1ef01f39f96e/fonc-10-547683-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/61438373d7f8/fonc-10-547683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d8/7907162/3f369c31f565/fonc-10-547683-g007.jpg

相似文献

1
Polysaccharides From Lentinus Edodes Inhibits Lymphangiogenesis the Toll-Like Receptor 4/JNK Pathway of Cancer-Associated Fibroblasts.香菇多糖通过Toll样受体4/JNK途径抑制癌症相关成纤维细胞的淋巴管生成。
Front Oncol. 2021 Feb 12;10:547683. doi: 10.3389/fonc.2020.547683. eCollection 2020.
2
MPSSS impairs the immunosuppressive function of cancer-associated fibroblasts via the TLR4-NF-κB pathway.MPSSS 通过 TLR4-NF-κB 通路损害癌症相关成纤维细胞的免疫抑制功能。
Biosci Rep. 2019 May 10;39(5). doi: 10.1042/BSR20182171. Print 2019 May 31.
3
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts.香菇多糖通过降低癌相关成纤维细胞 TGF-β1 的分泌来预防前列腺癌细胞获得多西紫杉醇耐药性。
J Nat Med. 2023 Sep;77(4):817-828. doi: 10.1007/s11418-023-01722-w. Epub 2023 Jun 24.
4
Proteomics reveals the function reverse of MPSSS-treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway.蛋白质组学揭示了 MPSSS 处理的前列腺癌相关成纤维细胞的功能逆转，通过 FoxO 通路抑制 PC-3 细胞活力。
Cancer Med. 2021 Apr;10(7):2509-2522. doi: 10.1002/cam4.3825. Epub 2021 Mar 11.
5
Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-κB/JNK pathways in colorectal cancer.脂多糖通过Toll样受体4-核因子κB/应激活化蛋白激酶途径增加血管内皮生长因子-C的释放，增强细胞运动性并促进结直肠癌的淋巴管生成和淋巴转移。
Oncotarget. 2016 Nov 8;7(45):73711-73724. doi: 10.18632/oncotarget.12449.
6
CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer.CCBE1 促进结直肠癌中的肿瘤淋巴管生成，并受 TGFβ 信号通路的负调控。
Theranostics. 2020 Jan 16;10(5):2327-2341. doi: 10.7150/thno.39740. eCollection 2020.
7
Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion.卡利他汀通过下调 VEGF-C 的表达和分泌抑制胃癌淋巴管生成和淋巴转移。
Gastric Cancer. 2018 Jul;21(4):617-631. doi: 10.1007/s10120-017-0787-5. Epub 2017 Dec 14.
8
Semaphorin 4D expression is associated with a poor clinical outcome in cervical cancer patients.信号素4D的表达与宫颈癌患者不良的临床预后相关。
Microvasc Res. 2014 May;93:1-8. doi: 10.1016/j.mvr.2014.02.007. Epub 2014 Mar 3.
9
Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion.血管内皮生长因子 C 破坏内皮淋巴管屏障促进结直肠癌侵袭。
Gastroenterology. 2015 Jun;148(7):1438-51.e8. doi: 10.1053/j.gastro.2015.03.005. Epub 2015 Mar 6.
10
A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway.一种肝素缀合物 LHbisD4 通过阻断 VEGF-C 信号通路抑制淋巴管生成并减轻淋巴结转移。
Biomaterials. 2017 Sep;139:56-66. doi: 10.1016/j.biomaterials.2017.05.026. Epub 2017 May 18.

引用本文的文献

1
Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment.癌症相关成纤维细胞中的旁分泌信号传导：肿瘤免疫微环境的核心调节因子
J Transl Med. 2025 Jun 23;23(1):697. doi: 10.1186/s12967-025-06744-4.
2
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier.蘑菇多糖在调节胃肠道稳态和保护胃肠道屏障中的作用。
J Agric Food Chem. 2025 Mar 19;73(11):6416-6441. doi: 10.1021/acs.jafc.5c00745. Epub 2025 Mar 10.
3
Immunomodulation aspects of gut microbiome-related interventional strategies in colorectal cancer.

本文引用的文献

1
Pazopanib Inhibits Tumor Growth, Lymph-node Metastasis and Lymphangiogenesis of an Orthotopic Mouse of Colorectal Cancer.帕唑帕尼抑制结直肠癌原位小鼠肿瘤生长、淋巴结转移和淋巴管生成。
Cancer Genomics Proteomics. 2020 Mar-Apr;17(2):131-139. doi: 10.21873/cgp.20173.
2
Effects of pericytes and colon cancer stem cells in the tumor microenvironment.肿瘤微环境中周细胞与结肠癌干细胞的作用
Cancer Cell Int. 2019 Jul 1;19:173. doi: 10.1186/s12935-019-0888-9. eCollection 2019.
3
MPSSS impairs the immunosuppressive function of cancer-associated fibroblasts via the TLR4-NF-κB pathway.
结直肠癌中与肠道微生物组相关的干预策略的免疫调节方面。
Med Oncol. 2024 Aug 20;41(9):231. doi: 10.1007/s12032-024-02480-9.
4
The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment.天然产物草药在 TLR4 信号通路治疗结直肠癌中的作用。
Molecules. 2024 Jun 7;29(12):2727. doi: 10.3390/molecules29122727.
5
Mycochemicals against Cancer Stem Cells.抗癌症干细胞的化感物质。
Toxins (Basel). 2023 May 25;15(6):360. doi: 10.3390/toxins15060360.
6
The Effect of Novel Selenopolysaccharide Isolated from Mycelium on Human T Lymphocytes Activation, Proliferation, and Cytokines Synthesis.新型硒多糖对人 T 淋巴细胞激活、增殖和细胞因子合成的影响。
Biomolecules. 2022 Dec 19;12(12):1900. doi: 10.3390/biom12121900.
7
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.脂肪酰基辅酶 A 去饱和酶 1 依赖性脂滴积累促进癌症相关成纤维细胞促进肺癌的进展。
Int J Biol Sci. 2022 Oct 18;18(16):6114-6128. doi: 10.7150/ijbs.74924. eCollection 2022.
8
Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model.基于植物的药用食品对胃癌术后复发和肺转移的影响：调控信号通路和 VEGF-C/D-VEGFR-3 级联的 Wnt/β-catenin-EMT 作用的小鼠模型。
BMC Complement Med Ther. 2022 Sep 2;22(1):233. doi: 10.1186/s12906-022-03703-0.
9
Ligustilide Inhibits Tumor Angiogenesis by Downregulating VEGFA Secretion from Cancer-Associated Fibroblasts in Prostate Cancer via TLR4.藁本内酯通过TLR4下调前列腺癌中癌相关成纤维细胞的VEGFA分泌来抑制肿瘤血管生成。
Cancers (Basel). 2022 May 13;14(10):2406. doi: 10.3390/cancers14102406.
10
Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NF-κB signaling pathway in lung adenocarcinoma.跨膜 p24 转运蛋白 2 通过 TLR4/NF-κB 信号通路在肺腺癌中调节炎症反应。
World J Surg Oncol. 2022 Feb 8;20(1):32. doi: 10.1186/s12957-021-02477-y.
MPSSS 通过 TLR4-NF-κB 通路损害癌症相关成纤维细胞的免疫抑制功能。
Biosci Rep. 2019 May 10;39(5). doi: 10.1042/BSR20182171. Print 2019 May 31.
4
Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China.香菇多糖作为一种免疫治疗药物治疗肺癌：中国 12 年临床研究综述。
J Cancer Res Clin Oncol. 2018 Nov;144(11):2177-2186. doi: 10.1007/s00432-018-2718-1. Epub 2018 Jul 24.
5
Identifying tumor promoting genomic alterations in tumor-associated fibroblasts via retrovirus-insertional mutagenesis.通过逆转录病毒插入诱变鉴定肿瘤相关成纤维细胞中促进肿瘤的基因组改变。
Oncotarget. 2017 Oct 16;8(57):97231-97245. doi: 10.18632/oncotarget.21881. eCollection 2017 Nov 14.
6
Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.肿瘤淋巴管生成促进 T 细胞浸润并增强黑色素瘤的免疫治疗。
Sci Transl Med. 2017 Sep 13;9(407). doi: 10.1126/scitranslmed.aal4712.
7
Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.成纤维网状细胞与B细胞之间的相互作用促进肠系膜淋巴结淋巴管生成。
Nat Commun. 2017 Aug 28;8(1):367. doi: 10.1038/s41467-017-00504-9.
8
Origins of lymphatic and distant metastases in human colorectal cancer.人类结直肠癌中淋巴转移和远处转移的起源
Science. 2017 Jul 7;357(6346):55-60. doi: 10.1126/science.aai8515.
9
High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer.高淋巴管密度和淋巴管浸润均提示乳腺癌预后不良。
BMC Cancer. 2017 May 17;17(1):335. doi: 10.1186/s12885-017-3338-x.
10
Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.巨噬细胞诱导的紫杉醇化疗后淋巴管生成和转移受血管内皮生长因子受体3（VEGFR3）调控。
Cell Rep. 2016 Oct 25;17(5):1344-1356. doi: 10.1016/j.celrep.2016.09.083.