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Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier.

作者信息

Liu Jianhui, Dai Yi, Yang Wenjian, Chen Zhen-Yu

机构信息

Collaborative Innovation Center for Modern Grain Circulation and Safety, Jiangsu Province Engineering Research Center of Edible Fungus Preservation and Intensive Processing, College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China.

School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong 999077, China.

出版信息

J Agric Food Chem. 2025 Mar 19;73(11):6416-6441. doi: 10.1021/acs.jafc.5c00745. Epub 2025 Mar 10.

DOI:10.1021/acs.jafc.5c00745
PMID:40063730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11926878/
Abstract

Edible and medicinal mushroom polysaccharides (EMMPs) have been widely studied for their various biological activities. It has been shown that EMMPs could modulate microbiota in the large intestine and improve intestinal health. However, the role of EMMPs in protecting the gastric barrier, regulating gastric microbiota, and improving gastric health cannot be ignored. Hence, this review will elucidate the effect of EMMPs on gastric and intestinal barriers, with emphasis on the interaction of EMMPs with microbiota in maintaining overall gastrointestinal health. Additionally, this review highlights the gastroprotective effects and underlying mechanisms of EMMPs against gastric mucosa injury, gastritis, gastric ulcer, and gastric cancer. Furthermore, the effects of EMMPs on intestinal diseases, including inflammatory bowel disease, colorectal cancer, and intestinal infection, are also summarized. This review will also discuss the future perspective and challenges in the use of EMMPs as a dietary supplement or a nutraceutical in preventing and treating gastrointestinal diseases.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/507668943f9f/jf5c00745_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/4bb45ee4643d/jf5c00745_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/a075c5ce74e2/jf5c00745_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/230b3b87bf4f/jf5c00745_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/507668943f9f/jf5c00745_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/4bb45ee4643d/jf5c00745_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/a075c5ce74e2/jf5c00745_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/230b3b87bf4f/jf5c00745_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b04/11926878/507668943f9f/jf5c00745_0004.jpg

相似文献

[1]
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier.

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[2]
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[3]
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引用本文的文献

[1]
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Animals (Basel). 2025-8-15

[2]
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本文引用的文献

[1]
Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis.

Int J Biol Macromol. 2024-5

[2]
Polysaccharide from Boletus aereus ameliorates DSS-induced colitis in mice by regulating the MANF/MUC2 signaling and gut microbiota.

Int J Biol Macromol. 2024-5

[3]
Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model.

Int J Biol Macromol. 2024-4

[4]
An Overview on Mushroom Polysaccharides: Health-promoting Properties, Prebiotic and Gut Microbiota Modulation Effects and Structure-function Correlation.

Carbohydr Polym. 2024-6-1

[5]
Polysaccharide from mycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota.

Food Funct. 2024-4-2

[6]
Structural Elucidation of a Polysaccharide from and Its Lipid-Lowering and Immunomodulation Activities.

Polymers (Basel). 2024-2-22

[7]
Structural characterization and anti-oxidant activity of polysaccharide HVP-1 from Volvariella volvacea.

Int J Biol Macromol. 2024-3

[8]
Novel Synthesis of Phytosterol Ferulate Using Acidic Ionic Liquids as a Catalyst and Its Hypolipidemic Activity.

J Agric Food Chem. 2024-1-31

[9]
Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.

Cancer Cell Int. 2023-12-16

[10]
Protective Properties of Intestinal Alkaline Phosphatase Supplementation on the Intestinal Barrier: Interactions and Effects.

J Agric Food Chem. 2024-1-10

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