Qi Yanyan, Wang Xi, Li Wenbo, Chen Dongchang, Meng Hua, An Songtao
Department of Cardiology, Anesthesiology and Emergency Medicine, Henan Province People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou, China.
Department of Cardiology, People's Hospital of Zhengzhou University, Zhengzhou, China.
Front Mol Biosci. 2021 Feb 10;7:622540. doi: 10.3389/fmolb.2020.622540. eCollection 2020.
Cardiovascular disease is the main disease that affects human life span. In recent years, the disease has been increasingly addressed at the molecular levels, for example, pseudogenes are now known to be involved in the pathogenesis and development of cardiovascular diseases. Pseudogenes are non-coding homologs of protein-coding genes and were once called "junk gene." Since they are highly homologous to their functional parental genes, it is somewhat difficult to distinguish them. With the development of sequencing technology and bioinformatics, pseudogenes have become readily identifiable. Recent studies indicate that pseudogenes are closely related to cardiovascular diseases. This review provides an overview of pseudogenes and their roles in the pathogenesis of cardiovascular diseases. This new knowledge adds to our understanding of cardiovascular disease at the molecular level and will help develop new biomarkers and therapeutic approaches designed to prevent and treat the disease.
心血管疾病是影响人类寿命的主要疾病。近年来，该疾病在分子水平上得到了越来越多的关注，例如，现已发现假基因参与心血管疾病的发病机制和发展过程。假基因是蛋白质编码基因的非编码同源物，曾被称为“垃圾基因”。由于它们与其功能性亲本基因高度同源，因此区分它们有点困难。随着测序技术和生物信息学的发展，假基因已变得易于识别。最近的研究表明，假基因与心血管疾病密切相关。本文综述了假基因及其在心血管疾病发病机制中的作用。这一新知识增加了我们在分子水平上对心血管疾病的理解，并将有助于开发旨在预防和治疗该疾病的新生物标志物和治疗方法。
