Department of Neurology, The Second People's Hospital of Deyang City, No. 340 Minjiang West Road, Deyang, Sichuan 618000, China.
Department of Neurology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan 646000, China.
Biomed Res Int. 2021 Feb 15;2021:6676144. doi: 10.1155/2021/6676144. eCollection 2021.
This study was aimed at investigating the relationship between serum amyloid A (SAA) levels and cognitive dysfunction in patients with vascular dementia (VAD).
Using cross-sectional research methods, 146 patients with VAD were selected as the VAD group and 70 normal people were selected as the NC group. Upon admission, the clinical and biochemical characteristics of the two groups of study subjects were collected, and the MMSE scale was used to assess cognitive function. A sandwich enzyme-linked immunosorbent assay was used to detect SAA levels.
There was no significant difference in clinical data and biochemical characteristics in the VAD group ( > 0.05). Compared with the VAD group, the NC group has a higher level of education ( < 0.05). The SAA level of the VAD group was higher than that of the NC group, and there was a significant difference ( < 0.05). Spearman correlation analysis showed that SAA and MMSE in the VAD group were negatively correlated. Further multiple regression analysis showed that the serum amyloid A level is an independent risk factor for cognitive dysfunction in VAD patients.
The level of SAA in VAD patients is significantly increased, which can be used as a potential peripheral blood marker to predict cognitive impairment in VAD patients.
本研究旨在探讨血清淀粉样蛋白 A（SAA）水平与血管性痴呆（VAD）患者认知功能障碍的关系。
采用横断面研究方法，选取 146 例 VAD 患者为 VAD 组，选取 70 名正常人作为 NC 组。两组研究对象入院时均采集临床及生化特征，采用 MMSE 量表评估认知功能，采用夹心酶联免疫吸附试验检测 SAA 水平。
VAD 组的临床资料和生化特征差异无统计学意义（>0.05）。与 VAD 组相比，NC 组受教育程度较高（<0.05）。VAD 组的 SAA 水平高于 NC 组，差异有统计学意义（<0.05）。Spearman 相关分析显示，VAD 组 SAA 与 MMSE 呈负相关。进一步的多元回归分析表明，血清淀粉样蛋白 A 水平是 VAD 患者认知功能障碍的独立危险因素。
VAD 患者的 SAA 水平显著升高，可作为预测 VAD 患者认知障碍的潜在外周血标志物。
