Defruyt Loran, Czapla Jens, Van Dorpe Jo, Ameloot Eline, Lemmens Gilbert, Timmermans Frank, De Backer Tine
Department of Cardiology, Ghent University Hospital, Ghent, Belgium.
Department of Cardiac Surgery, Ghent University Hospital, Ghent, Belgium.
CASE (Phila). 2020 Dec 7;5(1):86-88. doi: 10.1016/j.case.2020.11.003. eCollection 2021 Feb.
• Drug-induced valvular heart disease (DI-VHD) is reminiscent of carcinoid heart disease. • DI-VHD is mediated through 5-hydroxytryptamine 2β receptor signaling pathways. • Serotonergic agents interacting with this 2β receptor may cause carcinoid-like VHD. • DI-VHD must be considered in patients with no reasons for showing VHD and using SSRI. • Echocardiographic surveillance is warranted in patients on serotonergic drugs, including SSRI.
• 药物性瓣膜性心脏病（DI-VHD）类似于类癌性心脏病。
• DI-VHD通过5-羟色胺2β受体信号通路介导。
• 与该2β受体相互作用的5-羟色胺能药物可能会导致类癌样瓣膜性心脏病。
• 对于无瓣膜性心脏病表现且使用5-羟色胺再摄取抑制剂（SSRI）的患者，必须考虑DI-VHD。
• 对于正在使用包括SSRI在内的5-羟色胺能药物的患者，有必要进行超声心动图监测。
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