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在使用选择性5-羟色胺再摄取抑制剂情况下的左右侧类癌性心脏病

Right and Left-Sided Carcinoid Heart Disease in the Setting of Selective Serotonin Reuptake Inhibitor Use.

作者信息

Bell Jennifer, Alhudairy Maad, Kazakova Vera, Johnstone Michael, Tsao Lana

机构信息

Division of Cardiovascular Medicine, St. Elizabeth's Medical Center, Brighton, Massachusetts.

Department of Medicine, St. Elizabeth's Medical Center, Brighton, Massachusetts.

出版信息

JACC Case Rep. 2020 Oct;2(12):1841-1844. doi: 10.1016/j.jaccas.2020.07.060. Epub 2020 Oct 21.

DOI:10.1016/j.jaccas.2020.07.060
PMID:33106792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7577728/
Abstract

Carcinoid heart disease is a complication of carcinoid syndrome. The role of selective serotonin reuptake inhibitors in carcinoid heart disease is unclear. We present a case of refractory heart failure due to right- and left-sided carcinoid heart disease in the setting of selective serotonin reuptake inhibitor use despite remission of carcinoid syndrome. ().

摘要

类癌性心脏病是类癌综合征的一种并发症。选择性5-羟色胺再摄取抑制剂在类癌性心脏病中的作用尚不清楚。我们报告一例在使用选择性5-羟色胺再摄取抑制剂的情况下，尽管类癌综合征已缓解，但仍因左右侧类癌性心脏病导致难治性心力衰竭的病例。（）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/d683a0396996/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/b03eacc4272b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/caf35dfe9010/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/600d18047d63/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/d683a0396996/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/b03eacc4272b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/caf35dfe9010/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/600d18047d63/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcb/8299231/d683a0396996/gr3.jpg

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本文引用的文献

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Biochemical Testing in Neuroendocrine Tumors.神经内分泌肿瘤的生化检测。
Endocrinol Metab Clin North Am. 2017 Sep;46(3):669-677. doi: 10.1016/j.ecl.2017.04.004. Epub 2017 Jun 12.
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Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.芬氟拉明会破坏二尖瓣间质细胞对血清素的反应。
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Carcinoid heart disease: the role of urinary 5-hydroxyindoleacetic acid excretion and plasma levels of atrial natriuretic peptide, transforming growth factor-beta and fibroblast growth factor.类癌性心脏病：尿5-羟吲哚乙酸排泄及血浆心房利钠肽、转化生长因子-β和成纤维细胞生长因子水平的作用
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Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells.心脏瓣膜病中的5-羟色胺机制I：5-羟色胺通过主动脉瓣间质细胞中的G蛋白信号转导诱导转化生长因子-β1上调。
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