Lapuerta L, Chacos N, Falck J R, Jacobson H, Capdevila J H
Department of Biochemistry, University of Texas Health Science Center, Dallas.
Am J Med Sci. 1988 Apr;295(4):275-9. doi: 10.1097/00000441-198804000-00010.
Arachidonic acid is oxidized by the microsomal cytochrome P-450 monooxygenases of rabbit kidney cortex and medulla to products that include W and W-1 alcohols and several epoxyacids. In vivo administration of deoxycorticosterone acetate results in a time dependent and selective induction of the arachidonic acid W/W-1 oxygenase activity of cortex and medulla microsomal fractions (145% and 220% of controls, respectively). Initial segmental analysis shows the presence of an active epoxygenase activity in the isolated rabbit pars recta and its in vitro activation by p-aminohippuric acid.
花生四烯酸被兔肾皮质和髓质的微粒体细胞色素P-450单加氧酶氧化为包括W和W-1醇以及几种环氧酸在内的产物。体内给予醋酸脱氧皮质酮会导致皮质和髓质微粒体部分的花生四烯酸W/W-1加氧酶活性随时间依赖性和选择性诱导（分别为对照的145%和220%）。初步的节段分析表明，在分离的兔直部存在活性环氧合酶活性，并且其在体外被对氨基马尿酸激活。
