Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Lasers Med Sci. 2021 Sep;36(7):1527-1534. doi: 10.1007/s10103-021-03270-9. Epub 2021 Mar 1.
Diabetes mellitus is mostly interrelated to deficiency in wound healing. Low-level laser therapy has been shown to exert reliable effects on the acceleration of wound healing process. This study aimed to determine the potential influence of low-level laser therapy (LLLT) on the healing of extraction sockets in diabetic rats. A total of 24 healthy male Wistar rats were selected for this study. After diabetes induction, the maxillary first molars of all rats were extracted bilaterally. Then, the animals were subjected either to Ga-Al-As laser at 808 nm or to Al-Ga-In-P laser at 660 nm at the right extracted socket every day for the next 14 days. The left sockets served as controls. Rats were sacrificed on the 3rd, 5th, 7th, and 14th days after tooth extraction. The samples were examined by a pathologist. LLLT at 808 nm was able to significantly repress inflammation, improve osteoid formation, and promote vascularization in comparison to the non-treated sockets. LLLT at 660 nm significantly suppressed inflammation and developed vascularization in comparison to the non-treated sockets, but failed to improve osteoid formation in the treated sockets. This study suggests that LLLT could be considered as a reliable treatment for wound healing in diabetic experimental rats.
糖尿病大多与伤口愈合不良有关。低水平激光疗法已被证明对加速伤口愈合过程有可靠的效果。本研究旨在确定低水平激光疗法（LLLT）对糖尿病大鼠拔牙窝愈合的潜在影响。本研究共选择了 24 只健康雄性 Wistar 大鼠。糖尿病诱导后，所有大鼠的上颌第一磨牙均被双侧拔出。然后，动物在接下来的 14 天内每天在右侧拔牙窝接受 Ga-Al-As 激光（808nm）或 Al-Ga-In-P 激光（660nm）治疗。左侧拔牙窝作为对照。大鼠在拔牙后第 3、5、7 和 14 天被处死。病理学家对样本进行了检查。与未经处理的拔牙窝相比，808nm 的 LLLT 能够显著抑制炎症、改善类骨质形成并促进血管生成。与未经处理的拔牙窝相比，660nm 的 LLLT 显著抑制了炎症并促进了血管生成，但未能改善治疗拔牙窝中的类骨质形成。本研究表明，LLLT 可被视为糖尿病实验大鼠伤口愈合的可靠治疗方法。
