Zhang Pan, Zhang Yi-Fan, Chen Qun-Li, DU Wang-Chun, Yao Hong, Zhao Mei
Graduate School, Shanghai University of Chinese Medicine Shanghai 201203, China.
Department of Pharmacy, Shanghai University of Medicine & Health Sciences Shanghai 201318, China.
Zhongguo Zhong Yao Za Zhi. 2021 Jan;46(2):312-319. doi: 10.19540/j.cnki.cjcmm.20201015.601.
Breast tumor has become one of the malignant tumors with the highest incidence, and is a serious threat to human health, especially to women. Chemotherapy is an important anti-breast tumor therapy, which can be used in almost every stage of breast tumor therapy alone or in the combination with surgery and radiation therapy. Alkaloids are a kind of ubiquitous natural products, and important active components of various medicinal plants. A large number of studies have shown that alkaloids could exert an anti-breast tumor effect by inhibiting proliferation, metastasis and angiogenesis, resisting mitosis, promoting apoptosis and autophagy, and triggering cell cycle arrest. The extensive anti-breast tumor effect makes alkaloids an important candidate drug source. This paper reviews the anti-breast tumor mechanism of natural products of alkaloids.
乳腺癌已成为发病率最高的恶性肿瘤之一，严重威胁人类健康，尤其是女性健康。化疗是一种重要的抗乳腺癌治疗方法，几乎可单独用于乳腺癌治疗的各个阶段，也可与手术及放疗联合使用。生物碱是一类广泛存在的天然产物，是多种药用植物的重要活性成分。大量研究表明，生物碱可通过抑制增殖、转移和血管生成、抵抗有丝分裂、促进凋亡和自噬以及引发细胞周期停滞来发挥抗乳腺癌作用。生物碱广泛的抗乳腺癌作用使其成为重要的候选药物来源。本文综述了生物碱类天然产物的抗乳腺癌机制。
