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天然植物生物碱异喹啉的抗癌作用。

The Anticancer Effect of Natural Plant Alkaloid Isoquinolines.

机构信息

System Health & Engineering Major in Graduate School (BK21 Plus Program), Ewha Womans University, Seoul 03760, Korea.

Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.

出版信息

Int J Mol Sci. 2021 Feb 6;22(4):1653. doi: 10.3390/ijms22041653.

DOI:10.3390/ijms22041653
PMID:33562110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7915290/
Abstract

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.

摘要

富含异喹啉生物碱的草药植物一直被用作传统民间药物，具有抗炎、抗菌和镇痛作用。它们诱导细胞周期停滞、细胞凋亡和自噬，导致细胞死亡。虽然这些作用的分子机制尚不完全清楚，但有人认为异喹啉生物碱可能通过与核酸或蛋白质结合、抑制酶活性以及通过表观遗传调控来发挥作用。本文综述了异喹啉生物碱作为癌症治疗的治疗靶点的分子机制的最新证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/669b6f234f44/ijms-22-01653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/af0b3684ed65/ijms-22-01653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/a167408524ce/ijms-22-01653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/669b6f234f44/ijms-22-01653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/af0b3684ed65/ijms-22-01653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/a167408524ce/ijms-22-01653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9072/7915290/669b6f234f44/ijms-22-01653-g003.jpg

相似文献

[1]
The Anticancer Effect of Natural Plant Alkaloid Isoquinolines.

Int J Mol Sci. 2021-2-6

[2]
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[3]
Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer.

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[4]
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[5]
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Fitoterapia. 2016-4

[6]
[Progress of antibacterial activity and antibacterial mechanism of isoquinoline alkaloids].

Zhongguo Zhong Yao Za Zhi. 2016-7

[7]
Anti-inflammatory, Anti-bacterial and Anti-acetylcholinesterase Activities of two Isoquinoline Alkaloids-Scoulerine and Cheilanthifoline.

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[8]
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[9]
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[10]
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引用本文的文献

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RSC Adv. 2025-8-26

[2]
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Discov Oncol. 2025-7-17

[3]
Effect of Soil-Applied Metabolic Modulators on the Accumulation of Specialized Metabolites in L.

Molecules. 2025-6-27

[4]
Plant-derived products as anti-leishmanials which target mitochondria: a review.

Expert Rev Mol Med. 2025-3-26

[5]
The Phytochemical Profile of the Petroleum Ether Extract of Leaves and Its Anticancer Effect on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None (NNK)-Induced Lung Cancer in Rats.

Int J Mol Sci. 2024-12-4

[6]
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J Med Chem. 2024-11-14

[7]
Unveiling the impact of nitrogen deficiency on alkaloid synthesis in konjac corms (Amorphophallus muelleri Blume).

BMC Plant Biol. 2024-10-3

[8]
Allocryptopine Attenuates Inflammatory Responses in Microglial Cells Via TLR4-Dependent NF-κB and p38 MAPK Pathways.

Mol Neurobiol. 2025-3

[9]
Regioselective Synthesis of Cycloalkane-fused Pyrazolo[4,3-]pyridines through Tandem Reaction of 5-aminopyrazoles, Cyclic Ketones and Electron-rich Olefins.

Curr Org Synth. 2024

[10]
Multifaceted role of phytoconstituents based nano drug delivery systems in combating TNBC: A paradigm shift from chemical to natural.

Naunyn Schmiedebergs Arch Pharmacol. 2024-12

本文引用的文献

[1]
Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells.

Onco Targets Ther. 2020-11-24

[2]
Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway.

Int J Mol Sci. 2020-7-31

[3]
Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells.

Chem Biol Interact. 2020-6-24

[4]
Chelidonine selectively inhibits the growth of gefitinib-resistant non-small cell lung cancer cells through the EGFR-AMPK pathway.

Pharmacol Res. 2020-9

[5]
Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways.

Biomed Pharmacother. 2020-8

[6]
Ethoxysanguinarine, a Novel Direct Activator of AMP-Activated Protein Kinase, Induces Autophagy and Exhibits Therapeutic Potential in Breast Cancer Cells.

Front Pharmacol. 2020-1-8

[7]
Sanguinarine exhibits potent efficacy against cervical cancer cells through inhibiting the STAT3 pathway in vitro and in vivo.

Cancer Manag Res. 2019-8-14

[8]
Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant .

BMC Chem. 2019-2-4

[9]
Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G Arrest in the T98G Human Glioblastoma Cell Line.

Evid Based Complement Alternat Med. 2019-5-26

[10]
Promotion of Cell Death in Cisplatin-Resistant Ovarian Cancer Cells through KDM1B-DCLRE1B Modulation.

Int J Mol Sci. 2019-5-17

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