System Health & Engineering Major in Graduate School (BK21 Plus Program), Ewha Womans University, Seoul 03760, Korea.
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.
Int J Mol Sci. 2021 Feb 6;22(4):1653. doi: 10.3390/ijms22041653.
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.
富含异喹啉生物碱的草药植物一直被用作传统民间药物，具有抗炎、抗菌和镇痛作用。它们诱导细胞周期停滞、细胞凋亡和自噬，导致细胞死亡。虽然这些作用的分子机制尚不完全清楚，但有人认为异喹啉生物碱可能通过与核酸或蛋白质结合、抑制酶活性以及通过表观遗传调控来发挥作用。本文综述了异喹啉生物碱作为癌症治疗的治疗靶点的分子机制的最新证据。
