Dauman R, Aran J M, Charlet de Sauvage R, Portmann M
Laboratoire d'Audiologie Expérimentale, INSERM U.229, Université Bordeaux II, Hôpital Pellegrin, France.
Am J Otol. 1988 Jan;9(1):31-8.
Transtympanic (TT) electrocochleography (ECochG) data recorded with click stimuli and tone bursts (1, 2, 4, and 8 kHz) were evaluated in 50 patients with Meniere's disease and compared with the data from control groups of 10 sensorineural hearing impaired patients and 5 subjects with normal hearing. The mean summating potential (SP) amplitude was larger in the Meniere's disease group for 1, 2, and 8 kHz. The low frequency (1 or 2 kHz) SP decreased in 59% of the Meniere's disease patients during a glycerol dehydration test, whereas subjective hearing improved in only 29%. The use of ECochG with the monitoring of SP thus improves the sensitivity of the glycerol test for the detection of endolymphatic hydrops. There appeared no clear relation between clinical observations and the ECochG data either before or after glycerol. However, the Meniere's disease patients with a large negative SP at low frequencies also had larger action potential (AP) and often had short-term symptoms. The present report confirms the usefulness of measuring the SP in the diagnosis of Meniere's disease.
对50例梅尼埃病患者记录的经鼓膜（TT）电耳蜗图（ECochG）数据进行了评估，这些数据采用短声刺激和短纯音（1、2、4和8kHz）记录，并与10例感音神经性听力受损患者和5例听力正常受试者的对照组数据进行了比较。梅尼埃病组中1、2和8kHz的平均总和电位（SP）振幅更大。在甘油脱水试验期间，59%的梅尼埃病患者低频（1或2kHz）SP下降，而主观听力仅29%有所改善。因此，使用监测SP的ECochG可提高甘油试验对内淋巴积水检测的敏感性。甘油治疗前后的临床观察与ECochG数据之间均未发现明显关联。然而，低频时具有大的负SP的梅尼埃病患者也具有更大的动作电位（AP），且常伴有短期症状。本报告证实了测量SP在梅尼埃病诊断中的有用性。
