Goldspink D F, Douglas A J
Department of Physiology, Queen's University of Belfast, United Kingdom.
Am J Physiol. 1988 May;254(5 Pt 1):E549-54. doi: 10.1152/ajpendo.1988.254.5.E549.
Changes in uterine protein, RNA, and DNA contents in gravid and nongravid horns from the same animal were studied after 14 and 16 days of pregnancy. At 16 days, all of these parameters of growth had increased between three- and sevenfold in the gravid horn while remaining unchanged in the nongravid horn compared with the uterus of nonpregnant control animals. In the nongravid horn, the hormonal changes associated with pregnancy induced antagonistic decreases in both the average rates of protein synthesis and protein breakdown, with the net result being no change in its growth. In the gravid horn, however, the hormonal influences are coupled with the stretching effects produced by the enlarging fetuses. Here the net effect was a marked suppression of protein breakdown, resulting in a fourfold increase in its rate of growth. These data, together with those derived from analysis of both fetal and nonfetal sites from the gravid horn, led to the following conclusions. Changes in circulating hormones during pregnancy do not alone appear to influence the overall size of the uterus. In contrast, mechanical distension of the uterus promotes rapid and extensive growth.
在怀孕14天和16天后，对同一动物的妊娠角和非妊娠角中子宫蛋白质、RNA和DNA含量的变化进行了研究。在怀孕16天时，与未怀孕对照动物的子宫相比，妊娠角中所有这些生长参数增加了三到七倍，而非妊娠角则保持不变。在非妊娠角中，与妊娠相关的激素变化导致蛋白质合成和蛋白质分解的平均速率产生拮抗作用降低，最终结果是其生长没有变化。然而，在妊娠角中，激素影响与不断增大的胎儿产生的拉伸效应相结合。这里的净效应是蛋白质分解受到显著抑制，导致其生长速率增加了四倍。这些数据，连同从妊娠角的胎儿和非胎儿部位分析得出的数据，得出了以下结论。怀孕期间循环激素的变化似乎并不单独影响子宫的整体大小。相反，子宫的机械扩张促进了快速而广泛的生长。
