National Animal Health Research Centre, NARC, Lalitpur, Nepal.
Muna Veterinary Hospital, Lalitpur, Nepal.
Vet Med Sci. 2021 Jul;7(4):1211-1215. doi: 10.1002/vms3.458. Epub 2021 Mar 1.
Coxiella burnetii, a Gram-negative bacterium is a zoonotic agent causing coxiellosis in animals. Small ruminants and cattle are the primary reservoirs for human infection. This study was aimed to estimate the sero-prevalence of C. burnetii in the ruminants of the selected region in Nepal. Field visits were carried out at four sites in different geographical regions of Nepal. A total of 522 sera samples were collected from 118 sheep, 242 goats and 162 cattle with the history of abortion, anoestrus and infertility. Sera were tested for the presence of antibodies against C. burnetii using a commercially available ready-to-use ELISA test kit. The overall true sero-prevalence was 1.89% (95% CI: 0.33-3.45), the prevalence ranged between 4.35% and 23.21% in goats. Sero-prevalence in goat was higher than that of cattle and sheep which ascertained that total freedom from coxiellosis cannot be confirmed in Nepal. This could complement the impacts of other infectious causes of the infertility in the farm animals as well as the public health of the farming households.
贝氏考克斯体，一种革兰氏阴性细菌，是一种引起动物柯克斯氏体病的动物病原体。小反刍动物和牛是人类感染的主要宿主。本研究旨在估计尼泊尔选定地区反刍动物中贝氏考克斯体的血清流行率。在尼泊尔的四个不同地理区域的四个地点进行了实地考察。共从有流产、乏情和不孕史的 118 只绵羊、242 只山羊和 162 头牛中采集了 522 份血清样本。使用市售的即用型酶联免疫吸附试验试剂盒检测血清中针对 C. burnetii 的抗体存在情况。总真实血清流行率为 1.89%（95%CI：0.33-3.45），山羊的流行率在 4.35%至 23.21%之间。山羊的血清流行率高于牛和绵羊，这表明在尼泊尔不能完全确认无柯克斯氏体病。这可以补充其他导致农场动物不孕的传染病的影响，以及养殖家庭的公共卫生。
