Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Urology and Berlin Institute for Urologic Research, Berlin, Germany.
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiology, Berlin, Germany.
Clin Hemorheol Microcirc. 2021;78(3):259-269. doi: 10.3233/CH-201035.
Tissue Doppler imaging (TDI) uses the Doppler principle to quantify the movement of biological tissues.
To investigate the contribution of TDI parameters derived during magnetic resonance imaging and ultrasound (MRI/US) fusion-guided biopsy for prostate cancer (PCa) discrimination.
From March 2016 to Dec. 2018, 75 men with suspected PCa prospectively underwent fusion-guided prostate biopsy. TDI overlaid on predefined target lesion were compared to the confirmed contralateral tumor-free area of the prostate gland (using Image J). Diagnostic value of TDI parameters was assessed using histopathology as standard of reference.
Thirty-seven patients were diagnosed with PCa (49.3%), among them 27 with clinically significant PCa (Gleason score > 3 + 3 = 6 (ISUP 1). The LES/REF ratio was lower in confirmed PCa patients compared to patients without PCa (0.42, IQR, 0.22-0.59 vs. 0.52, IQR, 0.40-0.72, p = 0.017). TDI parameters allowed differentiation of low-risk from high-to-intermediate-risk PCa (ISUP 2 versus ISUP 3) based on lower pixel counts within the target ROI (1340, IQR 596-2430 vs. 2687, IQR 2453-3216, p = 0.004), lower pixel percentage (16.4 IQR 11.4-29.5 vs. 27.3, IQR 22.1-39.5; p = 0.005), and lower LES/REF ratios (0.29, IQR 0.19-0.51 vs. 0.52, IQR 0.47-0.74, p = 0.001).
TDI of prostate lesions prelocated by MRI discriminates between cancerous and noncancerous lesions and further seems to enable characterization of PCa aggressiveness. This widely available US technique may improve confidence in target lesion localization for tissue sampling.
组织多普勒成像（TDI）利用多普勒原理来量化生物组织的运动。
探讨磁共振成像（MRI）与超声（US）融合引导下前列腺癌（PCa）活检中 TDI 参数的作用。
2016 年 3 月至 2018 年 12 月，75 名疑似 PCa 的男性患者前瞻性地接受了融合引导下的前列腺活检。通过 Image J 将 TDI 叠加到预设的目标病变区域，并与前列腺肿瘤阴性区域（使用 Image J）进行比较。使用组织病理学作为标准参考来评估 TDI 参数的诊断价值。
37 名患者被诊断为 PCa（49.3%），其中 27 名患者为临床显著 PCa（Gleason 评分>3+3=6（ISUP 1）。与无 PCa 患者相比，确诊 PCa 患者的 LES/REF 比值较低（0.42，IQR，0.22-0.59 vs. 0.52，IQR，0.40-0.72，p=0.017）。TDI 参数可根据目标 ROI 内的像素计数（1340，IQR 596-2430 与 2687，IQR 2453-3216，p=0.004）、像素百分比（16.4 IQR 11.4-29.5 与 27.3，IQR 22.1-39.5；p=0.005）和 LES/REF 比值（0.29，IQR 0.19-0.51 与 0.52，IQR 0.47-0.74，p=0.001）较低，来区分低危和中高危 PCa。
MRI 定位的前列腺病变 TDI 可区分癌性和非癌性病变，并且似乎进一步能够对 PCa 的侵袭性进行特征描述。这种广泛应用的 US 技术可能会提高对组织取样目标病变定位的信心。
