血浆肌酸酐水平不能预测肌萎缩侧索硬化症的呼吸功能。
Plasma Creatinine Level Does Not Predict Respiratory Function in Amyotrophic Lateral Sclerosis.
机构信息
Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Departments of Neurology and Neuroscience, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom.
出版信息
J Neuromuscul Dis. 2021;8(5):795-799. doi: 10.3233/JND-200583.
In amyotrophic lateral sclerosis (ALS) lower plasma creatinine level has been associated with shorter survival and faster functional decline. It has not been clear if creatinine is associated with respiratory outcome. We analyzed retrospectively a population of unselected ALS patients. Multiple-regression and Cox-regression analyses were performed. We included 233 patients, mean age 62.8, mean disease duration of 18.6 months. At baseline, creatinine was significantly associated with ALSFRS-R, but not with its decline rate. No predictive value was disclosed for FVC, its decline rate, or with survival. We did not confirm that creatinine is a marker of respiratory outcome.
在肌萎缩侧索硬化症（ALS）中，较低的血浆肌酐水平与较短的生存期和更快的功能下降相关。肌酐是否与呼吸结局相关尚不清楚。我们回顾性分析了一组未经选择的 ALS 患者。进行了多元回归和 Cox 回归分析。我们纳入了 233 名患者，平均年龄 62.8 岁，平均疾病持续时间为 18.6 个月。在基线时，肌酐与 ALSFRS-R 显著相关，但与下降率无关。FVC、其下降率或生存率均无预测价值。我们没有证实肌酐是呼吸结局的标志物。
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