Department of Neurology, West China Hospital, Sichuan University, 37, Guo Xue Xiang, Chengdu, 610041, Sichuan, China.
Department of Neurology, Jiangbin Hospital, No 85 Hedi Road, Guangxi Zhuang Autonomous Region, Nanning, 530021, China.
Sci Rep. 2023 Sep 21;13(1):15695. doi: 10.1038/s41598-023-42075-4.
This study aimed to investigate the relationship between venous blood parameters and respiratory functions in patients with amyotrophic lateral sclerosis (ALS) and develop a model to predict respiratory impairment for individual patients with ALS. A total of 416 ALS patients were included in the study, and various hematologic and biochemical laboratory parameters as well as demographic and clinical factors were collected and compared. A multivariable logistic regression model was constructed to assess the association between FVC and venous blood biomarkers and clinical factors. The results showed that along with onset age, bulbar-onset, disease duration, BMI, eosinophil count (EO#), basophil count (BASO#), creatinine (CREA), uric acid (URCI) and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL/HDL) ratio were associated with reduced FVC. The area under the ROC curve is 0.735 for the test set and 0.721 for the validation set. The study also developed a relatively acceptable model for predicting respiratory impairment in ALS patients. These findings suggest that EO#, BASO#, CREA, URIC and LDL/HDL ratio can be useful in assessing FVC in ALS and can be easily accessible, accurate, and low-cost parameters.
本研究旨在探讨肌萎缩侧索硬化症（ALS）患者静脉血参数与呼吸功能之间的关系，并为个体 ALS 患者的呼吸功能障碍建立预测模型。共纳入 416 名 ALS 患者，收集并比较了各种血液学和生化实验室参数以及人口统计学和临床因素。构建了多变量逻辑回归模型，以评估 FVC 与静脉血生物标志物和临床因素之间的关系。结果表明，随着发病年龄、延髓发病、疾病持续时间、BMI、嗜酸性粒细胞计数（EO#）、嗜碱性粒细胞计数（BASO#）、肌酐（CREA）、尿酸（URCI）和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇（LDL/HDL）比值的增加，FVC 降低。验证集的 AUC 为 0.721。该研究还为预测 ALS 患者的呼吸功能障碍开发了一个相对可接受的模型。这些发现表明，EO#、BASO#、CREA、URIC 和 LDL/HDL 比值可用于评估 ALS 患者的 FVC，并且这些参数易于获取、准确且成本低廉。
