Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan.
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10106, Taiwan.
Mikrochim Acta. 2021 Mar 1;188(3):103. doi: 10.1007/s00604-021-04717-0.
Molybdenum disulfide (MoS) surface functionalization was performed with a catechol-containing polymer sodium alginate (SA) and dopamine (DA) through simultaneous MoS exfoliation and self-polymerization of DA. The MoS/SA-PDA nanocomposite was characterized using spectroscopic, microscopic, and electroanalytical techniques to evaluate its electrocatalytic performance. The electrocatalytic behavior of the MoS/SA-PDA nanocomposite modified electrode for the detection of acebutolol (ACE), a cardio-selective β-blocker drug was explored through cyclic voltammetric and differential pulse voltammetric techniques. The influence of scan rate, concentration, and pH value on the oxidation peak current of ACE was investigated to optimize the deducting condition. The electrochemical activity of the MoS/SA-PDA nanocomposite electrode was attributed to the existence of reactive functional groups being contributed from SA, PDA, and MoS exhibiting a synergic effect. The MoS/SA-PDA nanocomposite modified electrode exhibits admirable electrocatalytic activity with a wide linear response range (0.009 to 520 μM), low detection limit (5 nM), and high sensitivity (0.354 μA μM cm) also in the presence of similar (potentially interfering) compounds. The fabricated MoS/SA-PDA nanocomposite modified electrode can be useful for the detection of ACE in pharmaceutical analysis.
二硫化钼（MoS）表面功能化是通过同时进行 MoS 剥离和多巴胺（DA）的自聚合，用含有儿茶酚的聚合物海藻酸钠（SA）和多巴胺（DA）来实现的。使用光谱、显微镜和电化学分析技术对 MoS/SA-PDA 纳米复合材料进行了表征，以评估其电催化性能。通过循环伏安法和差分脉冲伏安法技术，研究了 MoS/SA-PDA 纳米复合材料修饰电极对心脏选择性β受体阻滞剂药物醋丁洛尔（ACE）的检测的电催化行为。研究了扫描速率、浓度和 pH 值对 ACE 氧化峰电流的影响，以优化扣除条件。MoS/SA-PDA 纳米复合材料电极的电化学活性归因于存在反应性官能团，这些官能团来自于 SA、PDA 和 MoS，它们表现出协同效应。MoS/SA-PDA 纳米复合材料修饰电极具有令人钦佩的电催化活性，具有宽线性响应范围（0.009 至 520 μM）、低检测限（5 nM）和高灵敏度（0.354 μA μM cm），在存在类似（潜在干扰）化合物的情况下也是如此。所制备的 MoS/SA-PDA 纳米复合材料修饰电极可用于药物分析中 ACE 的检测。
