一种新颖的胚胎质量评分系统，用于比较不同发育阶段的胚胎组。
A novel embryo quality scoring system to compare groups of embryos at different developmental stages.
机构信息
IVF Osaka Clinic, Higashi-Osaka, Osaka, 577-0012, Japan.
IVF Namba Clinic, Osaka, 550-0015, Japan.
出版信息
J Assist Reprod Genet. 2021 May;38(5):1123-1132. doi: 10.1007/s10815-021-02117-0. Epub 2021 Mar 1.
PURPOSE
To construct a new embryonic quality scoring system to compare groups of embryos at different developmental stages.
METHODS
Based on a hypothesis that the implantation potential of any embryo in an ovum pickup (OPU) cycle remains the same at any stage of development, be it day 2, 3, or 5, a new embryo quality scoring (EQS) system was designed. It was based on the analysis of the clinical results of 1610 single embryo transfers. We validated this scoring system in the comparison of embryonic quality between groups by evaluating the mean scores calculated at day 2, day 3, and day 5 for 957 embryos (150 cycles) from 3 different groups. We then compared EQSs of patients with pregnancy favorable factors (group A) such as young age and high AMH levels, with the patients with contra features (group B).
RESULTS
We confirmed that each mean EQS assessed at different stages of embryonic development within the same group was similar. The mean EQSs on day 3 and day 5 in group A were significantly higher than the mean EQSs on days 2, 3, and 5 in group B.
CONCLUSION
The novel EQS system proposed by us enables embryonic quality comparison between groups of embryos at different developmental stages.
目的
构建一种新的胚胎质量评分系统，以比较不同发育阶段的胚胎群体。
方法
基于任何胚胎在卵母细胞采集（OPU）周期中的着床潜力在任何发育阶段都保持不变的假设，设计了一种新的胚胎质量评分（EQS）系统。该系统基于对 1610 例单胚胎移植的临床结果进行分析。我们通过评估 3 个不同组的 957 个胚胎（150 个周期）在第 2、3 和 5 天计算的平均评分，验证了该评分系统在胚胎质量组间比较中的有效性。然后，我们比较了具有妊娠有利因素（如年龄较小和 AMH 水平较高）的患者（A 组）与具有相反特征的患者（B 组）的 EQS。
结果
我们证实，同一组内不同胚胎发育阶段的每个平均 EQS 评估值相似。A 组第 3 天和第 5 天的平均 EQS 明显高于 B 组第 2、3 和 5 天的平均 EQS。
结论
我们提出的新型 EQS 系统能够比较不同发育阶段的胚胎群体的胚胎质量。
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