Department of Internal Medicine, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic.
Department of Dermatology, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic.
Prague Med Rep. 2021;122(1):45-51. doi: 10.14712/23362936.2021.6.
Malignant melanoma is commonly known for its high probability of metastasizing to distant organs. Metastases to gastrointestinal tract are well documented, but resulting jaundice is only scarcely seen. We present a case of histologically verified metastasis of amelanotic melanoma to the head of pancreas infiltrating the common bile duct and consequently causing obstructive jaundice which constituted its first clinical manifestation. Multidisciplinary approach is essential in patients with malignant melanoma since early detection of the melanoma or its metastases may improve patients' clinical outcome, especially owing to the use of targeted biological treatment without any delay.
恶性黑色素瘤通常以其向远处器官转移的高概率而闻名。胃肠道转移已有充分的记载，但由此导致的黄疸则很少见。我们报告了一例组织学证实的无黑色素性黑色素瘤转移至胰头，浸润胆总管，进而导致梗阻性黄疸，这是其首次临床表现。对于恶性黑色素瘤患者，多学科方法至关重要，因为早期发现黑色素瘤或其转移瘤可能会改善患者的临床结局，尤其是由于可以立即使用靶向生物治疗而无需任何延迟。
