Department of Big Data in Health Science and Center for Clinical Big Data and Analytics, Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Orthopedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Exp Gerontol. 2021 Jun;148:111290. doi: 10.1016/j.exger.2021.111290. Epub 2021 Feb 27.
Vitamin D deficiency is common among older adults, but its association with physical function is not fully understood. The aim of this study was to investigate the associations between serum 25-hydroxyvitamin D and disability in activities of daily living (ADL), mobility, and objective physical functioning among Chinese older adults.
We used cross-sectional data of 2225 older adults (≥65 years) who participated in the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study. Serum levels of 25-hydroxyvitamin D were measured by enzyme immunoassay. Outcomes included ADL disability, mobility disability, and disability in three objective physical examinations (standing-up from a chair, picking-up a book from the floor, and turning-around 360°).
The multiple regression models suggested that participants in the serum 25-hydroxyvitamin D deficiency group had higher odds of ADL disability (OR: 4.08; 95% confidence interval (CI): 2.81, 5.92), mobility disability (OR: 1.59; 95% CI: 1.05, 2.41), and disability in standing-up from a chair (OR: 2.43; 95% CI: 1.60, 3.69), picking-up a book from the floor (OR: 3.09; 95% CI: 2.07, 4.60), and turning-around 360° (OR: 3.09; 95% CI: 2.07, 4.60). Subgroup analyses revealed that some of the above associations (particularly those with mobility disability and disability in turning-around 360°) were only statistically significant among the oldest-old.
Among the oldest-old in China, serum 25-hydroxyvitamin D deficiency was associated with disability in ADL, mobility, and objective physical functioning, highlighting the importance of managing the serum 25-hydroxyvitamin D level to promote healthy aging.
维生素 D 缺乏在老年人中很常见，但它与身体功能的关系尚不完全清楚。本研究旨在探讨中国老年人血清 25-羟维生素 D 与日常生活活动（ADL）、活动能力和客观身体功能障碍之间的关系。
我们使用了参加 2011/2012 年中国长寿纵向研究（CLHLS）主调查和 2012 年生物标志物子研究的 2225 名老年人（≥65 岁）的横断面数据。采用酶联免疫吸附法检测血清 25-羟维生素 D 水平。结局包括 ADL 障碍、活动能力障碍和三项客观身体检查（从椅子上站起来、从地板上捡起一本书、360°转身）的障碍。
多元回归模型表明，血清 25-羟维生素 D 缺乏组的参与者 ADL 障碍（OR：4.08；95%置信区间（CI）：2.81，5.92）、活动能力障碍（OR：1.59；95% CI：1.05，2.41）和从椅子上站起来的障碍（OR：2.43；95% CI：1.60，3.69）、从地板上捡起一本书（OR：3.09；95% CI：2.07，4.60）和 360°转身的障碍（OR：3.09；95% CI：2.07，4.60）的可能性更高。亚组分析显示，其中一些关联（特别是与活动能力障碍和 360°转身障碍相关的关联）仅在最老年组中具有统计学意义。
在中国的最老年人群中，血清 25-羟维生素 D 缺乏与 ADL、活动能力和客观身体功能障碍有关，强调了管理血清 25-羟维生素 D 水平以促进健康老龄化的重要性。
