Department of Big Data in Health Science and Center for Clinical Big Data and Analytics, Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Orthopedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Maturitas. 2022 Jul;161:12-17. doi: 10.1016/j.maturitas.2022.01.018. Epub 2022 Feb 11.
This study aimed to examine the associations of plasma superoxide dismutase (SOD) activity, an indicator of oxidative stress, with disability in activities of daily living (ADL) and objective physical functioning among Chinese older adults.
We used cross-sectional data of 2223 older adults (≥65 years, including 1505 adults≥80 years) from the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study. Plasma SOD activity was assessed by the T-SOD assay kit based on the hydroxylamine method. Outcomes included ADL disability and disability in three objective physical tasks (standing up from a chair, picking up a book from the floor, and turning around 360°). Logistic regression models were used to examine the associations of plasma SOD activity with outcomes.
After controlling for age and sex, compared with participants in the lowest quartile group of SOD activity, those in the highest quartile group had 31% lower odds of ADL disability (odds ratio [OR]: 0.69; 95%CI: 0.48, 0.98); 60% lower odds of disability in standing up from a chair (OR: 0.40; 95%CI: 0.25, 0.63); and 57% lower odds of disability in picking up a book from a floor (OR: 0.43; 95%CI: 0.28, 0.65). The results did not change substantially after controlling for additional covariates. We did not observe statistically significant age and sex differences.
Overall, plasma SOD activity was associated with subjectively and objectively measured disability in Chinese older adults, highlighting the potential of SOD activity to serve as a biomarker of physical functioning.
本研究旨在探讨血浆超氧化物歧化酶（SOD）活性这一氧化应激指标与中国老年人日常生活活动（ADL）残疾和客观身体功能的关系。
我们使用了中国长寿纵向研究（CLHLS）2011/2012 年主调查和 2012 年生物标志物子研究中 2223 名（≥65 岁，包括 1505 名≥80 岁）老年人的横断面数据。采用羟胺法基于 T-SOD 测定试剂盒检测血浆 SOD 活性。结局包括 ADL 残疾和三项客观身体任务（从椅子上站起来、从地板上捡起书、转身 360°）的残疾。采用逻辑回归模型检验血浆 SOD 活性与结局的关系。
在校正年龄和性别后，与 SOD 活性最低四分位组的参与者相比，SOD 活性最高四分位组的 ADL 残疾的可能性降低了 31%（比值比[OR]：0.69；95%可信区间[CI]：0.48，0.98）；从椅子上站起来的残疾可能性降低了 60%（OR：0.40；95%CI：0.25，0.63）；从地板上捡起书的残疾可能性降低了 57%（OR：0.43；95%CI：0.28，0.65）。在控制其他协变量后，结果变化不大。我们没有观察到统计学上显著的年龄和性别差异。
总体而言，血浆 SOD 活性与中国老年人主观和客观测量的残疾有关，这强调了 SOD 活性作为身体功能生物标志物的潜力。
