Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Organization of African Unity St., 11566, Abbassia, Cairo, Egypt.
Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Organization of African Unity St., 11566, Abbassia, Cairo, Egypt.
Microb Pathog. 2021 May;154:104809. doi: 10.1016/j.micpath.2021.104809. Epub 2021 Feb 27.
Amid the COVID-19 outbreak, several bioinformatic analyses have been conducted on SARS-CoV-2 virus genome. Numerous studies rushed to fill the gap about this novel virus. Comparison with other related sequences, structural predictions of the produced proteins, determination of variations in amino acid residues and depiction of possible drug and vaccine targets have been the focus of scientific research from the beginning of this year. In addition to discussing the viral taxonomy, clinical features, life cycle, and genome organization, this review will focus on the recent updates in genome and viral proteins characterization and potential therapeutic and vaccine candidates developed so far. Comparative studies with related genomes and proteins provide understanding for the viral molecular mechanisms and suggest targets for therapeutics and vaccinology trials to stop the escalation of this new virus. This pandemic, with its resulting social and economic afflictions, will definitely have significant marks on our lives in the following years.
在 COVID-19 疫情期间，针对 SARS-CoV-2 病毒基因组进行了多项生物信息学分析。许多研究都急于填补有关这种新型病毒的空白。从今年年初开始，研究的重点是与其他相关序列进行比较、预测产生的蛋白质的结构、确定氨基酸残基的变异以及描绘可能的药物和疫苗靶点。除了讨论病毒分类学、临床特征、生命周期和基因组组织外，本综述还将重点介绍基因组和病毒蛋白特征的最新进展，以及迄今为止开发的潜在治疗和疫苗候选物。与相关基因组和蛋白质的比较研究为病毒的分子机制提供了理解，并为治疗学和疫苗学试验提供了靶点，以阻止这种新病毒的蔓延。这场大流行及其带来的社会和经济影响，肯定会在未来几年给我们的生活留下深刻的印记。
