Departments of Pathology, North Hospital, University Hospital of St-Etienne, France.
Departments of Pathology, North Hospital, University Hospital of St-Etienne, France.
Pathol Res Pract. 2021 Apr;220:153392. doi: 10.1016/j.prp.2021.153392. Epub 2021 Feb 18.
Tumors lymphocytic infiltration has prognostic and predictive value. However, the mechanisms involved in lymphocyte recruitment remain poorly characterized. High endothelial venules (HEV) are blood vessels specialized in lymphocyte recruitment, recently showing prognostic significance in some types of cancer. Their implications in laryngeal or pharyngeal cancer is largely unknown.
To investigate the possible presence of HEVs in head and neck cancer.
Oropharyngeal (n = 61), hypopharyngeal (n = 53) and laryngeal (n = 21) squamous cell carcinomas were immunohistochemically studied with the MECA-79 antibody, which specifically recognizes HEVs. Histological and clinical factors were correlated with HEVs' presence.
HEVs were present in 34% of tumors, showing significant correlations with oropharyngeal localization, higher lymphocytic response, lower tumor budding, lower T status, absence of distant metastases and better overall and progression-free survival.
HEVs represent an important prognostic factor in head and neck cancer.
肿瘤淋巴细胞浸润具有预后和预测价值。然而，淋巴细胞募集的相关机制仍知之甚少。高内皮微静脉（HEV）是专门用于淋巴细胞募集的血管，最近在某些类型的癌症中显示出预后意义。它们在喉癌或口咽癌中的意义尚不清楚。
研究头颈部癌症中是否存在 HEV。
对 61 例口咽癌、53 例下咽癌和 21 例喉癌进行免疫组化研究，使用 MECA-79 抗体特异性识别 HEV。将组织学和临床因素与 HEV 的存在进行相关性分析。
HEV 存在于 34%的肿瘤中，与口咽部位、更高的淋巴细胞反应、更低的肿瘤芽生、更低的 T 分期、无远处转移以及更好的总生存期和无进展生存期显著相关。
HEV 是头颈部癌症的一个重要预后因素。
