Tang L J, Zhang X W, Jin J J, Li X M, Xu G
The First Clinical College of Dalian Medical University, Dalian 116044, China.
Department of Burns and Plastic Surgery of Subei People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou 225001, China.
Zhonghua Shao Shang Za Zhi. 2021 Feb 20;37(2):191-195. doi: 10.3760/cma.j.cn501120-20200220-00076.
Exosomes are a kind of membrane vesicle with a diameter of 30-150 nm. It is formed by the budding of multiple vesicles in cells, which can fuse with the cell membrane and be released into the extracellular matrix. Adipose derived stem cells (ADSCs) have the potential of self-renewal and multi-directional differentiation. They can transport the active substance, regulate the inflammatory response, cell migration, proliferation, differentiation and angiogenesis via the action of paracrine exosomes, so as to enhance the ability of wound repair, promote wound healing, and inhibit the formation of scars. Chronic wounds refer to the wounds that can not reach the anatomic and functional integrity through the normal, orderly, and timely repair process, and the course of the wound healing is more than 4 weeks. At present, there are various treatment methods for chronic wounds, among which ADSCs, although showing a good application prospect, have some limitations due to ethical issues, while exosomes can avoid this problem. This article reviews the treatment of chronic wounds with ADSC exosomes.
外泌体是一种直径为30 - 150纳米的膜泡。它由细胞内多个囊泡出芽形成，可与细胞膜融合并释放到细胞外基质中。脂肪来源干细胞（ADSCs）具有自我更新和多向分化的潜能。它们可通过旁分泌外泌体的作用运输活性物质，调节炎症反应、细胞迁移、增殖、分化及血管生成，从而增强伤口修复能力，促进伤口愈合，并抑制瘢痕形成。慢性伤口是指无法通过正常、有序且及时的修复过程达到解剖和功能完整性的伤口，其伤口愈合过程超过4周。目前，慢性伤口有多种治疗方法，其中ADSCs虽显示出良好的应用前景，但因伦理问题存在一些局限性，而外泌体可避免这一问题。本文综述了ADSC外泌体治疗慢性伤口的研究。
