Yao Y Z, Deng C L, Wang B
Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
Zhonghua Shao Shang Za Zhi. 2018 Sep 20;34(9):653-656. doi: 10.3760/cma.j.issn.1009-2587.2018.09.017.
Adipose-derived stem cells (ADSCs) are adult mesenchymal stem cells in adipose tissue with self-renewal and multi-directional differentiation potential. The application of ADSCs in the treatment of wounds has achieved good results. Because of its extensive sources, high content in vivo, low immunogenicity, slight injury to body when obtained, the clinical application prospect of ADSCs is promising. The reasons why diabetic wound is difficult to heal may be closely related to the increase of advanced glycation end products, long-term chronic inflammatory response, and peripheral neurologic dysfunction. The abnormal internal environment of diabetic patients can affect the biological function of ADSCs, which further affects wound healing. This article reviews the general feature, differentiation, proliferation, migration, secretion, and pro-angiogenic function of diabetic ADSCs.
脂肪来源干细胞（ADSCs）是存在于脂肪组织中的成人间充质干细胞，具有自我更新和多向分化潜能。ADSCs在伤口治疗中的应用已取得良好效果。由于其来源广泛、体内含量高、免疫原性低、获取时对机体损伤小，ADSCs的临床应用前景广阔。糖尿病伤口难以愈合的原因可能与晚期糖基化终末产物增加、长期慢性炎症反应以及周围神经功能障碍密切相关。糖尿病患者异常的体内环境会影响ADSCs的生物学功能，进而影响伤口愈合。本文综述了糖尿病ADSCs的一般特征、分化、增殖、迁移、分泌及促血管生成功能。
