Faculty of Science, Department of Organic Chemistry, University of YaoundéI 1, Yaoundé, Cameroon.
Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Nat Prod Res. 2022 Mar;36(6):1467-1475. doi: 10.1080/14786419.2021.1891054. Epub 2021 Mar 1.
Twenty indole alkaloids, among which two undescribed ones named rauvolfianoids A () and B (), were isolated from the stem barks of Sond along with eight other compounds from other biosynthetic pathways. The structures were elucidated by analysis of spectroscopic data, including 1 D and 2 D NMR; absolute configurations of and were determined by CD exciton chirality method. Compounds and were evaluated for antimicrobial and anticancer activities against three bacterial strains (, and ) and CRC-related opportunistic pathogens. showed moderate antibacterial activity against with the MIC value of 25 μg/ml, while exhibited weak selective activity against all tested pathogens. In addition, these alkaloids were characterized as weak apoptosis inducers in HCT116 human colon carcinoma cell line.
从 Sond 的茎皮中分离得到了 20 种吲哚生物碱，其中两种未被描述的化合物分别命名为 rauvolfianoids A()和 B()，此外还从其他生物合成途径中分离得到了 8 种其他化合物。通过分析包括 1D 和 2D NMR 在内的光谱数据，阐明了这些化合物的结构；通过 CD 激子手性法确定了和的绝对构型。评估了化合物和对三种细菌菌株（、和）和 CRC 相关机会性病原体的抗菌和抗癌活性。表现出对具有 MIC 值为 25 μg/ml 的中度抗菌活性，而表现出对所有测试病原体的弱选择性活性。此外，这些生物碱在 HCT116 人结肠癌细胞系中表现出较弱的凋亡诱导作用。
