Hao Wu, Ma-Long Qin, Kun Fan, Wen Gao, Rui-Rong Guo, Shan-Ze Yin, Wei-Yan Hu, Lan-Chun Zhang, Rong-Ping Zhang, Hao-Fei Yu, Yu-Peng Li, Cai-Feng Ding
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650031, China.
Yunnan Key Laboratory of Southern Medicinal Resources, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
J Asian Nat Prod Res. 2023 May;25(5):429-437. doi: 10.1080/10286020.2022.2104258. Epub 2022 Aug 5.
Two new monoterpenoid indole alkaloids 3-hydroxylochnerine () and 10-hydroxyvinorine () were isolated from the roots of . Their structures were elucidated based on the analysis of spectroscopic data and ECD calculation. Both compounds exhibited potent antimicrobial activity against and , and their activities were comparable to the well-known antibacterial drug berberine.
从[植物名称]的根中分离出两种新的单萜吲哚生物碱3-羟基洛希宁（）和10-羟基长春瑞宁（）。基于光谱数据分析和ECD计算确定了它们的结构。这两种化合物对[微生物名称1]和[微生物名称2]均表现出强大的抗菌活性，且它们的活性与著名的抗菌药物黄连素相当。
