颅脑损伤中的 Tau 成像。

Tau Imaging in Head Injury.

机构信息

Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

出版信息

PET Clin. 2021 Apr;16(2):249-260. doi: 10.1016/j.cpet.2020.12.009.

DOI:10.1016/j.cpet.2020.12.009

PMID:33648666

Abstract

Tau proteins play a significant role in a variety of degenerative neurologic conditions. Postmortem neuropathology studies of victims of repeat and severe head trauma have defined a unique spatial expression of neurologic tauopathies in these individuals, known as chronic traumatic encephalopathy. Established and newly developed radiotracers are now being applied to head injury populations with the intent of diagnosis and disease monitoring. This review assesses the role of tau in head injury, the state of tau radiotracer development, and the potential clinical value of tau-PET as derived from head injury studies.

摘要

tau 蛋白在多种神经退行性疾病中发挥着重要作用。对重复性和严重头部创伤受害者的死后神经病理学研究定义了这些个体中神经 tau 病的独特空间表达，称为慢性创伤性脑病。目前正在将现有的和新开发的放射性示踪剂应用于头部损伤人群，旨在进行诊断和疾病监测。本综述评估了 tau 在头部损伤中的作用、tau 放射性示踪剂的发展现状以及来自头部损伤研究的 tau-PET 的潜在临床价值。