Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Eur Cytokine Netw. 2020 Dec 1;31(4):118-128. doi: 10.1684/ecn.2020.0460.
Both the innate and adaptive arms of the immune system are involved in the development of autoimmune diseases. The main mechanism of disease is due to adaptive immune cells that are active against self-antigens. These cells can cause major damage to body tissues. Innate lymphoid cells (ILCs) are an important type of innate immune cell, whose role has been highlighted in recent years. ILCs are responsible for some of the inflammation in the pathogenesis of autoimmune diseases. In this review, we discuss the role of ILCs in the immune response, as well as their involvement in various autoimmune diseases.
免疫系统的固有和适应性免疫都参与了自身免疫性疾病的发生。疾病的主要机制是由于针对自身抗原的适应性免疫细胞活跃。这些细胞会对身体组织造成严重损伤。先天淋巴细胞 (ILC) 是一种重要的先天免疫细胞，近年来其作用已得到强调。ILC 在自身免疫性疾病发病机制中的炎症反应中起作用。在这篇综述中，我们讨论了 ILC 在免疫反应中的作用，以及它们在各种自身免疫性疾病中的参与。
