Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
APHM, Hôpital de la Timone, Service de Médecine Interne, Marseille, France.
Nat Rev Immunol. 2017 Nov;17(11):665-678. doi: 10.1038/nri.2017.86. Epub 2017 Aug 14.
Recent years have seen a marked increase in our understanding of innate lymphoid cells (ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets in terms of their expression of key transcription factors and cytokine production. Various immunological functions of ILCs have been described, and increasing numbers of studies have implicated these cells in inflammatory disorders. Here, we detail the roles of ILCs in inflammatory diseases; we cover type 2 inflammatory diseases (such as asthma, chronic rhinosinusitis and atopic dermatitis), as well as inflammatory bowel diseases, psoriasis and other systemic or organ-specific inflammatory and autoimmune diseases. Future directions in the field are discussed, together with potential avenues of treatment.
近年来，我们对先天淋巴细胞（ILC）的认识有了显著提高。根据关键转录因子表达和细胞因子产生的相似性，ILC 可分为不同的群。ILC 的各种免疫功能已被描述，越来越多的研究表明这些细胞与炎症性疾病有关。在这里，我们详细介绍了 ILC 在炎症性疾病中的作用；涵盖了 2 型炎症性疾病（如哮喘、慢性鼻-鼻窦炎和特应性皮炎）以及炎症性肠病、银屑病和其他全身性或器官特异性炎症和自身免疫性疾病。还讨论了该领域的未来方向以及潜在的治疗途径。
