Pfreundschuh M, Mommertz E, Meissner M, Feller A C, Hassa R, Krueger G R, Diehl V
Medizinische Universitätsklinik, Köln, F.R.G.
Anticancer Res. 1988 Mar-Apr;8(2):217-24.
The two monoclonal antibodies HRS-1 and HRS-2, which were obtained after immunization with the Hodgkin's derived cell line L428, detect different epitopes on a 120 kd antigen. This antigen is present on Hodgkin- and Reed-Sternberg (H&RS) cells in all subtypes of Hodgkin's lymphoma and on large cell anaplastic non-Hodgkin's lymphomas. The H&RS- associated 120 kd antigen appears to be a non-lineage specific activation antigen, as it is not present on normal B and T lymphocytes or monocytes, but appears on these cells after activation. Because of their restricted reactivity with H&RS cells, HRS-1 and HRS-2 alone or in combination may be helpful for immunoimaging and immunotherapy of Hodgkin's lymphomas.
用霍奇金淋巴瘤衍生细胞系L428免疫后获得的两种单克隆抗体HRS - 1和HRS - 2，可检测到一种120kd抗原上的不同表位。该抗原存在于所有霍奇金淋巴瘤亚型的霍奇金和里德 - 斯腾伯格（H&RS）细胞以及大细胞间变性非霍奇金淋巴瘤中。与H&RS相关的120kd抗原似乎是一种非谱系特异性激活抗原，因为它不存在于正常B淋巴细胞、T淋巴细胞或单核细胞上，但在这些细胞激活后会出现。由于HRS - 1和HRS - 2与H&RS细胞的反应具有局限性，单独或联合使用它们可能有助于霍奇金淋巴瘤的免疫显像和免疫治疗。
