在单中心四级新生儿重症监护病房重新审视早产儿支气管肺发育不良的定义。
Revisiting the definition of bronchopulmonary dysplasia in premature infants at a single center quaternary neonatal intensive care unit.
机构信息
NewYork- Presbyterian Children's Hospital of New York, Columbia University Medical Center, New York, NY, USA.
出版信息
J Perinatol. 2021 Apr;41(4):756-763. doi: 10.1038/s41372-021-00980-4. Epub 2021 Mar 1.
OBJECTIVE
To compare the incidence of bronchopulmonary dysplasia (BPD) based on the 1988 Vermont Oxford Network (VON) criteria, National Institutes of Health (NIH) 2001 definition, and NIH 2018 definition.
METHODS
BPD incidence by each definition was compared in premature infants born at a single center between 2016 and 2018. Comorbidities were compared between those with and without BPD according to the newest definition.
RESULTS
Among 352 survivors, BPD incidence was significantly different at 9%, 28% and 34% according to VON, NIH 2001 and NIH 2018 definitions, respectively (p < 0.05). According to the newest definition, any grade of BPD was associated with more co-morbidities than those without BPD (P < 0.001).
CONCLUSION
At a center that emphasizes use of early noninvasive respiratory support, the incidence of BPD was significantly higher according to the NIH 2018 definition compared to other two definitions. The relationship between BPD diagnosis and long-term clinical outcomes remains unclear.
目的
比较基于 1988 年佛蒙特州牛津网络（VON）标准、美国国立卫生研究院（NIH）2001 年定义和 NIH 2018 年定义的支气管肺发育不良（BPD）发生率。
方法
比较 2016 年至 2018 年在单中心出生的早产儿根据每个定义的 BPD 发生率。根据最新定义，比较有和无 BPD 的患儿之间的合并症。
结果
在 352 名幸存者中，VON、NIH 2001 和 NIH 2018 定义的 BPD 发生率分别为 9%、28%和 34%，差异有统计学意义（p<0.05）。根据最新定义，任何程度的 BPD 与无 BPD 患儿相比，合并症更多（P<0.001）。
结论
在一个强调早期无创呼吸支持的中心，根据 NIH 2018 年的定义，BPD 的发生率明显高于其他两个定义。BPD 诊断与长期临床结局之间的关系仍不清楚。
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