Division of Neonatal and Perinatal Medicine, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
J Perinatol. 2024 Sep;44(9):1285-1290. doi: 10.1038/s41372-024-02014-1. Epub 2024 May 31.
We aim to describe neonatal respiratory outcomes following previable preterm premature rupture of membranes(PPROM) when gentle ventilation is utilized. We also report maternal morbidity and mortality.
This is a retrospective single-center cohort study of infants delivered between 2016 and 2020 that included infants born at ≥23 weeks without major congenital anomaly after a pregnancy complicated with PPROM before 23 weeks gestation. Statistical analysis utilized unpaired Student's t-test or Mann-Whitney U-test when appropriate.
35 infants from 33 pregnancies were included. 91.4% of infants survived until discharge and 12.1% developed Bronchopulmonary Dysplasia (BPD). Those who developed BPD had significantly lower amniotic fluid levels prior to delivery (p < 0.05). There was no significant maternal morbidity or mortality in this cohort.
This cohort had high survival and low rates of respiratory morbidities. This suggests the use of gentle ventilation might be the optimal strategy for patients born after previable PPROM.
我们旨在描述在使用温和通气的情况下，极早产儿胎膜早破（PPROM）后的新生儿呼吸结局。我们还报告了产妇的发病率和死亡率。
这是一项回顾性单中心队列研究，纳入了 2016 年至 2020 年期间分娩的婴儿，这些婴儿在妊娠 23 周前发生的极早产儿胎膜早破后，在 23 周胎龄后出生，无主要先天性异常。统计分析在适当的情况下使用了未配对的学生 t 检验或曼-惠特尼 U 检验。
33 例妊娠中有 35 例婴儿纳入研究。91.4%的婴儿存活至出院，12.1%的婴儿发展为支气管肺发育不良（BPD）。那些发展为 BPD 的婴儿在分娩前的羊水水平明显较低（p<0.05）。本队列中无产妇发病率或死亡率。
该队列的存活率高，呼吸并发症发生率低。这表明，对于极早产儿胎膜早破后出生的患者，使用温和通气可能是最佳策略。
