Huang Lin-Yi, Lin Ting-I, Lin Chyi-Her, Yang San-Nan, Chen Wan-Ju, Wu Chien-Yi, Liu Hsien-Kuan, Wu Pei-Ling, Suen Jau-Ling, Chen Jung-Sheng, Yang Yung-Ning
Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
Children (Basel). 2023 Nov 17;10(11):1822. doi: 10.3390/children10111822.
Bronchopulmonary dysplasia (BPD) is a major respiratory condition mainly affecting premature infants. Although its occurrence is global, risk factors may differ regionally. This study, involving 3111 infants with birth weight ≤ 1500 gm or gestational age (GA) < 30 weeks, aimed to identify risk factors for BPD and BPD/mortality in Taiwan using data from the Taiwan Neonatal Network. The BPD criteria were based on the National Institute of Child Health and Human Development standards. Average GA was 27.5 weeks, with 23.7% classified as small for GA (SGA). Multivariate analysis highlighted low GA, low birth weight, and other perinatal factors as significant risk indicators for BPD. For moderate-to-severe BPD, additional risk factors included male gender and SGA, endotracheal intubation (ETT) or cardiopulmonary cerebral resuscitation (CPCR) in initial resuscitation. In the moderate-to-severe BPD/death group, SGA and ETT or CPCR in initial resuscitation remained the only additional risk factors. The study pinpoints male gender, SGA and ETT or CPCR as key risk factors for moderate-to-severe BPD/death in low-birth-weight infants in Taiwan, offering a basis for focused interventions and further research.
支气管肺发育不良（BPD）是一种主要影响早产儿的严重呼吸系统疾病。尽管其在全球范围内都有发生，但风险因素可能因地区而异。本研究纳入了3111例出生体重≤1500克或胎龄（GA）<30周的婴儿，旨在利用台湾新生儿网络的数据确定台湾地区BPD及BPD/死亡率的风险因素。BPD的诊断标准基于美国国立儿童健康与人类发展研究所的标准。平均胎龄为27.5周，23.7%的婴儿为小于胎龄儿（SGA）。多变量分析强调低胎龄、低出生体重及其他围产期因素是BPD的重要风险指标。对于中重度BPD，额外的风险因素包括男性性别、SGA、初始复苏时的气管插管（ETT）或心肺脑复苏（CPCR）。在中重度BPD/死亡组中，SGA以及初始复苏时的ETT或CPCR仍然是仅有的额外风险因素。该研究指出男性性别、SGA以及ETT或CPCR是台湾低出生体重婴儿中重度BPD/死亡的关键风险因素，为针对性干预和进一步研究提供了依据。
