口服活性炭对妥布霉素清除率的影响。
Effect of oral activated charcoal on tobramycin clearance.
作者信息
Davis R L, Koup J R, Roon R A, Opheim K E, Smith A N
机构信息
College of Pharmacy, University of New Mexico, Albuquerque 87131.
出版信息
Antimicrob Agents Chemother. 1988 Feb;32(2):274-5. doi: 10.1128/AAC.32.2.274.
Abstract
To evaluate the effect of activated charcoal on aminoglycoside pharmacokinetics, six healthy volunteers received tobramycin intravenously with and without multiple oral doses of activated charcoal. Activated charcoal did not have a statistically significant effect on any pharmacokinetic parameter. We conclude that activated charcoal does not enhance tobramycin clearance in subjects with normal renal function when concentrations in serum are within the therapeutic range.
摘要
为评估活性炭对氨基糖苷类药物药代动力学的影响，六名健康志愿者在静脉注射妥布霉素时，分别接受了多次口服活性炭和未接受口服活性炭的处理。活性炭对任何药代动力学参数均无统计学上的显著影响。我们得出结论，当血清浓度处于治疗范围内时，活性炭不会增强肾功能正常受试者体内妥布霉素的清除率。
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2
Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man.活性炭对人体内苯巴比妥、卡马西平和保泰松吸收及消除的影响。
Eur J Clin Pharmacol. 1980 Jan;17(1):51-7. doi: 10.1007/BF00561677.
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Effect of activated charcoal on the pharmacokinetics of high-dose methotrexate.
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The aminoglycosides.氨基糖苷类抗生素。
Med Clin North Am. 1982 Jan;66(1):303-12. doi: 10.1016/s0025-7125(16)31462-6.
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