Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
J Cardiovasc Transl Res. 2021 Oct;14(5):921-929. doi: 10.1007/s12265-021-10106-y. Epub 2021 Mar 1.
Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r = 0.38, p<0.001 and r = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.
心绞痛和非阻塞性冠状动脉疾病（CAD）的预后不佳，可能是由于弥漫性心肌纤维化（DMF）所致。在 DMF 中，蛋白聚糖核心蛋白聚糖和 versican 通过基质金属蛋白酶进行积极重塑。我们研究了女性心绞痛和可能的 DMF 中核心蛋白聚糖和 versican 的情况，通过心脏磁共振（CMR）评估。纳入了 71 名患有心绞痛和非阻塞性 CAD 的女性。无症状女性作为对照组。测量了 versican 和核心蛋白聚糖，并进行了 CMR 以测量细胞外体积。与对照组相比，有症状的女性的核心蛋白聚糖和 versican 水平更高；31.4ng/mL 比 16.4ng/mL（p<0.001）和 2.1ng/mL 比 1.8ng/mL（p<0.001），并与细胞外体积中度相关（r=0.38，p<0.001 和 r=0.26，p=0.015）。与对照组相比，心绞痛女性的核心蛋白聚糖和 versican 周转率增加，与细胞外体积相关，这表明无阻塞性 CAD 的心绞痛与纤维重塑之间存在联系。
