Pardo Mindán F J, Panizo A
Department of Pathology, Clínica Universitaria, University of Navarra, Pamplona, Spain.
Eur Heart J. 1993 Nov;14 Suppl J:12-4.
Hypertension produces myocyte hypertrophy and increases the extracellular matrix. In order to determine the composition of the extracellular matrix we studied the hearts from 14 hypertensive patients by immunohistochemistry using antibodies against collagen I, III, IV and V, fibronectin, myoglobin, muscular specific actin, Factor VIII, CD 34 and vimentin. The myocardium showed a focal increase in fibronectin, collagen I and III and diffuse deposition of laminin, collagen IV and V. Cells positive for vimentin, Factor VIII and CD 34 were also increased, but with considerable variation from case to case. We found no relation between matrix variation and the degree of hypertension or the time elapsed from the beginning of the disease. We conclude that the main role of the matrix in hypertension may be remodelling of the heart so that it entraps muscle fibres and increases their contractility.
高血压会导致心肌细胞肥大并增加细胞外基质。为了确定细胞外基质的组成，我们通过免疫组织化学方法，使用针对I型、III型、IV型和V型胶原蛋白、纤连蛋白、肌红蛋白、肌肉特异性肌动蛋白、VIII因子、CD 34和波形蛋白的抗体，对14例高血压患者的心脏进行了研究。心肌显示纤连蛋白、I型和III型胶原蛋白局部增加，层粘连蛋白、IV型和V型胶原蛋白弥漫性沉积。波形蛋白、VIII因子和CD 34阳性的细胞也增加，但病例之间存在相当大的差异。我们发现基质变化与高血压程度或疾病开始后的时间长短无关。我们得出结论，基质在高血压中的主要作用可能是心脏重塑，从而包裹肌肉纤维并增加其收缩力。
