Song Li, Chen Run-Zhen, Zhao Xiao-Xiao, Sheng Zhao-Xue, Zhou Peng, Liu Chen, Li Jian-Nan, Zhou Jin-Ying, Wang Ying, Zhao Han-Jun, Yan Hong-Bing
Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, No. 167, Beilishi Road, Beijing, 100037, China.
Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, No. 12, Langshan Road, Shenzhen, 518000, China.
J Cardiovasc Transl Res. 2021 Dec;14(6):1093-1103. doi: 10.1007/s12265-021-10113-z. Epub 2021 Mar 1.
This study aimed to investigate the predictive value of mean platelet volume/platelet count ratio (MPR) for coronary plaque features in patients with ST segment elevation myocardial infarction (STEMI). A total of 275 STEMI patients undergoing preintervention optical coherence tomography examination were included, with 142 categorized as plaque rupture (PR) and 133 as plaque erosion (PE). Multivariable logistic regression showed higher MPR was an independent predictor of PR (tertile 3 vs tertile 1, odds ratio: 6.257, 95% confidence interval: 1.586-24.686, P = 0.009). MPR showed better diagnostic performance than other platelet indices. The optimal MPR threshold for diagnosing PR was 0.0473 (sensitivity: 0.721, specificity: 0.647). When added to models of established risk factors, MPR significantly improved the predictive accuracy of PR (area under the curve: 0.767 vs 0.722, P = 0.004). In conclusion, for STEMI patients, MPR was an independent predictor of PR and improved diagnostic performance for PR.
本研究旨在探讨平均血小板体积/血小板计数比值（MPR）对ST段抬高型心肌梗死（STEMI）患者冠状动脉斑块特征的预测价值。共纳入275例接受干预前光学相干断层扫描检查的STEMI患者，其中142例归类为斑块破裂（PR），133例为斑块侵蚀（PE）。多变量逻辑回归显示，较高的MPR是PR的独立预测因素（三分位数3与三分位数1相比，比值比：6.257，95%置信区间：1.586 - 24.686，P = 0.009）。MPR的诊断性能优于其他血小板指标。诊断PR的最佳MPR阈值为0.0473（敏感性：0.721，特异性：0.647）。当将其添加到既定危险因素模型中时，MPR显著提高了PR的预测准确性（曲线下面积：0.767对0.722，P = 0.004）。总之，对于STEMI患者，MPR是PR的独立预测因素，并提高了PR的诊断性能。
