Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, Bucharest, Romania.
Faculty of Dental Medicine, "Titu Maiorescu" University, Bucharest, Romania.
Adv Exp Med Biol. 2021;1335:11-35. doi: 10.1007/5584_2021_626.
Inflammation is deeply involved in the development of most types of cancer. Many studies focus on the interaction between immune-inflammatory mechanisms and tumorigenesis in the head and neck squamous cell carcinoma (HNSCC). In this chapter, we emphasize the complexity of processes underlying this interaction and discuss the mechanisms of carcinogenesis in HNSCC with a special focus on metabolic changes, inflammation, and the immune landscape. Unveiling complex connections between immuno-inflammatory processes and tumor initiation, promotion, and progression will open new directions in the reliable identification of predictive factors and therapeutic targets in HNSCC.
炎症在大多数类型癌症的发展中都有很深的牵连。许多研究都集中在头颈部鳞状细胞癌（HNSCC）中的免疫炎症机制与肿瘤发生之间的相互作用。在这一章中，我们强调了这种相互作用背后的过程的复杂性，并讨论了 HNSCC 中致癌的机制，特别关注代谢变化、炎症和免疫景观。揭示免疫炎症过程与肿瘤起始、促进和进展之间的复杂联系，将为可靠地鉴定 HNSCC 中的预测因子和治疗靶点开辟新的方向。
